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  • 1
    Electronic Resource
    Electronic Resource
    Plasma and urinary digoxin in thyroid dysfunction (1977)
    Springer
    European journal of clinical pharmacology 12 (1977), S. 437-443 
    Details
    ISSN: 1432-1041
    Keywords: Digoxin ; hypothyroid ; hyperthyroid ; thyroid dysfunction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The response to a single oral dose of 0.5 mg digoxin has been studied in eight patients, of whom four were hyperthyroid and four were hypothyroid, both before and after treatment for their thyroid dysfunction. The post-dose plasma digoxin levels were significantly lower in the hyperthyroid patients when they were thyrotoxic than when they became euthyroid. In only one hypothyroid patient was the post-dose plasma digoxin level significantly higher before treatment than it was after and in the others the digoxin values reached were either the same as, or lower than, before treatment. There was a significant correlation between the creatinine clearance and the urinary concentrations of digoxin and these both altered with change in thyroid status. Total urinary digoxin excretion did not change. Pharmacokinetic analysis suggested that digoxin was distributed in a way compatible with a two-compartment model and that the volume of the central compartment was high in thyrotoxic patients and low in hypothyroid patients. In both cases it reverted to a median value after treatment. It is recommended that plasma digoxin levels should be monitored in all patients with thyroid dysfunction who require therapeutic digoxin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561063
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Confocal fluorescence and Raman microscopy in industrial research (1998)
    Springer
    Colloid & polymer science 276 (1998), S. 577-588 
    Details
    ISSN: 1435-1536
    Keywords: Key words Confocal microscopy ; confocal Raman microscopy ; chemical imaging ; laser scanning confocal microscopy ; two-photon-microscopy ; fluorescence correlation spectroscopy ; Raman correlation spectroscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract  Modern chemical and pharmaceutical industrial research benefits from improved spectroscopic tools. New developments in confocal fluorescence and Raman microscopy lead to an increase in sensitivity, selectivity and speed of microscopic imaging and fluctuation analysis resulting in a better understanding of structure–property relationships essential for targeted development. In this paper we report on the application of fluorescence and Raman microscopy for characterizing the morphology of polymeric multiphase solid-state samples and on new developments in the corresponding correlation spectroscopies for the characterization of the dynamics of complex colloidal systems in the liquid state. In the case of fluorescence new technological opportunities are gained by two-photon excitation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003960050284
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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