ISSN:
1432-069X
Keywords:
Key words Adamantiades-Behçet’s disease (A-BD)
;
Interleukin-8 (IL-8)
;
Superoxide dismutase (SOD)
;
Inflammation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Serum interleukin-8 (IL-8) production was measured in 43 Adamantiades-Behçet’s disease (A-BD) patients and in 46 healthy volunteers using a sandwich enzyme-linked immunosorbent assay (ELISA). The mean serum IL-8 level of the patients (14.6 ± 3 pg/ml) was significantly higher than that of controls (10.8 ± 3 pg/ml, P 〈 0.05). Since IL-8 is known to have proinflammatory properties, it may play some role in the pathogenesis of A-BD. We also investigated the activity of serum superoxide dismutase (SOD) in the 43 patients with A-BD and in the 46 healthy volunteers. Serum SOD activity was markedly increased in the patients with A-BD (13.1 ± 3%), especially in active A-BD, compared with that in the healthy volunteers (6.7 ± 3%, P 〈 0.01). Our results suggest the involvement of IL-8 and SOD in the pathogenesis of A-BD as seen in other inflammatory diseases.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004030050219
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