ISSN:
1434-4726
Keywords:
Key words Cochlea
;
Aminoglycoside toxicity
;
Hair cell apoptosis
;
Nick-end labeling
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Although aminoglycosides have been investigated for their cochleotoxicity, it has still not been determined whether apoptosis or necrosis results in cochlear hair cell death following aminoglycoside treatment. To study possible mechanisms of cell death, we used in situ DNA break-labeling to examine guinea pig cochleae affected by kanamycin ototoxicity. Chronic kanamycin treatment induced DNA fragmentation that was detectable in both outer and inner hair cells, suggesting the occurrence of apoptosis. These findings suggest that apoptosis achieves deletion of affected hair cells without disrupting tissue architecture in the organ of Corti.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004050050027
Permalink
