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  • 1
    Digitale Medien
    Digitale Medien
    Involvement of endothelin in graft-versus-host disease after rat small bowel transplantation (1997)
    Springer
    Transplant international 10 (1997), S. 121-124 
    Details
    ISSN: 1432-2277
    Schlagwort(e): Key words Endothelin ; small bowel transplantation ; rat ; Small bowel transplantation ; rat ; endothelin ; Graft-versus-host disease ; endothelin ; small bowel transplantation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Endothelin (ET-1) expression was evaluated by radioimmunoassay in both plasma and various tissue specimens serially obtained from LBN-F1 recipients of LEW heterotopic small bowel allografts. The recipients showed graft-versus-host disease (GVHD), which histologically became apparent on postoperative day (POD) 13. The ET-1 levels peaked on POD 9 in the kidney, lung, and host intestine at 51.0 ± 21.1, 90.9 ± 59.6, and 25.4 ± 11.8 pg/g wet, respectively, and peaked on POD 11 in the plasma at 7.7 ± 3.2 pg/ml; thereafter, they decreased to basal levels in both the plasma and tissue specimens on POD 13. An immunohistochemical study of these organs showed a corresponding increase in ET-1 staining in both the endothelial and epithelial cells on PODs 5 and 9, and a reduction in staining on POD 13. In conclusion, ET-1 was found to be increasingly released from the target cells of GVHD before any histological changes became apparent, thus suggesting the pathophysiological involvement of ET-1 in intestinal GVHD.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s001470050024
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    The role of ventricular and cisternal drainage in the early operation for ruptured intracranial aneurysms (1987)
    Springer
    Acta neurochirurgica 88 (1987), S. 87-94 
    Details
    ISSN: 0942-0940
    Schlagwort(e): Early aneurysm surgery ; continuous ventricular and cisternal drainage ; delayed ischemic neurological deficit ; outcome after aneurysm surgery
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In a series of 177 patients with ruptured supratentorial aneurysms we studied retrospectively the results of early and delayed operation without aggressive removal of subarachnoid blood clots but ventricular and cisternal drainage. The early and delayed groups were comparable demographically and neurologically. The overall results for the early group were a good outcome in 65%, poor outcome in 10% and death in 24%, compared to 53, 20 and 27% respectively in the delayed group. Thus, patients with an early operation and CSF drainage had better results. Permanent ischaemic neurological deficits due to cerebral vasospasm accounted for the poor outcome in 10 and 21% of the patients in the early and delayed groups, respectively and rebleeding accounted for the poor outcome in 5 and 10% in the early and delayed groups respectively. The mean amount of haemoglobin in the cerebrospinal fluid from cisternal drainage was 6.4 g, corresponding to about 40 ml of whole blood, during the 12-day period after SAH. The level was higher in patients with larger subarachnoid clots or with symptomatic vasospasm than in those with smaller clots or without such vasospasm. Early operation combined with ventricular and cisternal drainage is considered to be a useful surgical method for patient with a ruptured aneurysm.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01404143
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  • 3
    Digitale Medien
    Digitale Medien
    The effect of cyclosporin on endothelin levels after orthotopic liver transplantation in rats (1997)
    Springer
    Transplant international 10 (1997), S. 207-211 
    Details
    ISSN: 1432-2277
    Schlagwort(e): Key words Endothelin ; liver transplantation ; rat ; Cyclosporin ; endothelin ; rat liver transplantation ; Liver transplantation ; endothelin ; rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract To assess the effects of cyclosporin (CyA) on endothelin-1 (ET-1) in rat liver allograft rejection, we evaluated ET-1 expression in samples obtained from BN(RT1n)-to-BN (group 1) rats, DA(RT1a)-to-BN (group 2) rats, and DA-to-BN rats treated with 5 mg/kg per day of CyA (group 3). Serum and hepatic ET-1 levels, determined by a radioimmunoassay, remained unchanged in group 1. In group 2, the ET-1 levels peaked on postoperative day (POD) 5 in the liver at 344 ± 31.6 pg/g wet, and on POD 7 in the serum at 38.7 ± 13.1 pg/ml. In group 3, hepatic and renal ET-1 levels showed a progressive increase until POD 10, while serum ET-1 levels remained unchanged. In conclusion, acute rejection caused a temporary increase in the ET-1 level in both the serum and the liver in the early postoperative period what might have been caused by endothelial damage due to ongoing, acute rejection. CyA caused a time-dependent increase in the ET-1 level in both the liver and the kidney without an increase in the serum ET-1 level. The serum ET-1 level might have been affected by the clearance of ET from the liver or kidney.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s001470050043
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