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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nuclear medicine 13 (1987), S. 432-438 
    ISSN: 1619-7089
    Keywords: 153Sm ; Radiolanthanides ; Chelates ; Melanoma ; Endoradiotherapy ; Radionuclide imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 153Sm, a radiolanthanide of half life 46.27 h, has a gamma emission of 0.103 MeV which is well suited to imaging, it is also a moderate energy beta emitter and tumour localization of various 153Sm chelates was evaluated in B16 murine melanoma to assess their endoradiotherapeutic potential. 153Sm was prepared from enriched 152Sm in the Australian Nuclear Science and Technology Organization reactor. 153Sm chelates were prepared from 153Smchloride and their chromatographic behaviour characterized. Tumour and organ uptake of 153Sm-chloride, 153Sm-citrate and the 153Sm chelates, DTPA, HEDTA, HIDA, BZ, PBH, PIH and NTA were measured at 1, 6, 24 and 48 h after intravenous administration to C57 black mice bearing either melanotic or amelanotic B16 melanoma of mean size 0.75 cm3. Histopathological examination of the tumours at each passaging assured comparability of the degree of melanogenesis and the absence of necrosis. 153Sm-chloride was immobile on chromatography and the rapid hepatic accumulation of both 153Sm-chloride and 153Sm-citrate was attributed to in vivo formation of a colloid. In contrast, 153Sm-DTPA, moving at the solvent front on chromatography, showed no reticuloendothelial accumulation in vivo and was rapidly excreted by the kidneys without tumour uptake. The other 153Sm chelates were of intermediate stability and all localized in both melanotic and amelanotic tumours, although to a significantly lesser degree than 67Ga-citrate. The relatively high 153Sm-HIDA activity in liver and 153Sm-NTA activity in bone impaired tumour definition, but on imaging of all the 153Sm chelates only 153Sm-DTPA failed to demonstrate the B16 melanoma and the best tumour delineation was obtained using 153Sm-HEDTA.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    HNO 48 (2000), S. 527-532 
    ISSN: 1433-0458
    Keywords: Schlüsselwörter Laryngitis gastrica ; Omeprazol ; Key words Laryngitis gastrica ; Omeprazol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract We treated 64 patients with the diagnosis of laryngitis gastrica with Antra (Omeprazol) in doses of 10, 20, and 40 mg. To determine the success of the therapy, pH monitoring of the esophagus and hypopharynx, the voice status and measurement of vocal penetrating capacity were used. The results prove that a 20-mg dose of Antra is suitable for the therapy of laryngitis gastrica with a high rate of success. Problems which arose during the investigation, consequent changes of the original concept of the project as well as new aspects and questions which resulted from this are discussed with respect to further investigation.
    Notes: Zusammenfassung In einem Therapieversuch werden 64 Patienten mit der Diagnose Laryngitis gastrica mit Antra (Omeprazol) in unterschiedlicher Dosierung, 10, 20, und 40 mg, behandelt. Zur Beurteilung des Therapieerfolgs werden die pH-Metrie des Ösophagus und Hypopharynx, die Laryngoskopie, Mikrostroboskopie, der Stimmstatus und die Messung der stimmlichen Durchdringungsfähigkeit herangezogen. Das Ergebnis zeigt, dass mit Antra (Omeprazol) in der Dosierung 2-mal 20 mg ein geeignetes Medikament zur Therapie der Laryngitis gastrica mit hoher Erfolgsquote zur Verfügung steht. Es werden Probleme bei der Durchführung der Studie, dadurch bedingte Abweichungen von der ursprünglichen Konzeption des Projekts, sowie daraus resultierende neue Gesichtspunkte und Fragestellungen für weitere Untersuchungen diskutiert.
    Type of Medium: Electronic Resource
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