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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 126 (2000), S. 595-600 
    ISSN: 1432-1335
    Keywords: Key words Liver cancer ; Tumor metastasis ; Adhesion ; β Peptide ; Intercellular adhesion molecule-1
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: To study the inhibitory effects of synthetic β peptide on invasion and metastasis of liver cancer. Methods: Membrane-type intercellular adhesion molecule-1 (ICAM-1) expression of SMMC-7721 cultured hepatoma cells (7721 cells) was detected by immunofluorescence cell flowmeter. The adhesion of 7721 cells to fibronectin (FN) was assayed by the MTT method. The adhesion of 7721 cells to 7721 cells, 7721 cells to endothelial cells, and 7721 cells to lymphocyte cells was detected by adhesion assay. LCI-D20 human liver cancer metastasis model in nude mice was used in this experiment. One hundred micrograms of β peptide per mouse were injected subcutaneously after tumor was resected premetastatically or postmetastatically to observe its effect on liver cancer metastasis after hepatectomy. Results: Membrane-type ICAM-1 expression of SMMC-7721 cells treated by β peptide was lower than that of the untreated cells. The adhesion of 7721 cells to FN, 7721 cells to 7721 cells, 7721 cells to endothelial cells, and 7721 cells to lymphocyte cells was also lower in the β peptide group than in the untreated group. Conclusions:β Peptide can block the adhesion of 7721 cells to FN, 7721 cells to some host cells in vitro, and inhibit HCC metastasis of LCI-D20 model posthepatectomy in vivo, so it could potentially act as an anti-metastasis drug.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Oxidation of metals 51 (1999), S. 317-331 
    ISSN: 1573-4889
    Keywords: OXIDATION ; γ-TiAl INTERMETALLIC ; ELECTRODEPOSITEDNi-La2O3 ; COMPOSITE FILM
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract A coating of nickel withLa2O3 particles waselectrodeposited on the surface of γ-TiAl toimprove its high-temperature oxidation resistance. Theexperimental results showed that contrary to theoxidation of bare specimens, the electrodepositedNi-La2O3 composite-coated onesexhibited much better resistance to both isothermal andcyclic oxidation in air at 1000 and 900°C. For theoxidation of the Ni-La2O3 composite-coated γ-TiAl EPMA/EDX microanalyses revealed that after the composite film had beenthoroughly oxidized, a La2O3-richNiO layer close to the gas-scale interface and twoalumina-rich layers, with one beneath the NiO layer and the otheradjacent to the γ-TiAl matrix, were produced inthe scale. The results indicated that the preferentiallyformed La2O3-doped NiO layerretarded the growth of rutile and favored the formation of twoalumina-rich layers. The mechanism of the effect of theelectrodeposited Ni-La2O3composite on the oxidation behavior of γ-TiAl isdiscussed in detail.
    Type of Medium: Electronic Resource
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