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  • Human platelets  (1)
  • K^+  (1)
  • Key words Palmaz-Schatz-Stent – AVE-Micro-Stent – restenosis-rate – high pressure implantation – morphology of stenosis  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Biomembranes 771 (1984), S. 245-248 
    ISSN: 0005-2736
    Keywords: (E. coli) ; Ion flux ; K^+ ; Rb^+ ; Virus infection
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1435-1285
    Keywords: Key words Palmaz-Schatz-Stent – AVE-Micro-Stent – restenosis-rate – high pressure implantation – morphology of stenosis ; Schlüsselwörter Palmaz-Schatz-Stent – AVE-Micro-Stent – Restenoserate – Hochdruckimplantation – Stenosemorphologie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Late results of interventional procedures utilizing coronary stents are largely determined by the rate of restenosis. So far few data are available addressing the effect of stent design, implantation pressure and morphologic factors on this crucial variable. Therefore we analyzed the coronary angiogramms obtained in 259 patients before, immediately after and at 3 to 6 months following stent implantation for obstructive coronary disease. A total of 196 AVE-Micro-Stents and 142 Palmaz-Schatz-Stents were implanted into 307 stenoses. In 126 stenoses there were implanted only Palmaz-Schatz-Stents, in 170 only AVE-Micro-Stents and in 11 Stenoses there were implanted Palmaz-Schatz- as well as Micro-Stents. Restenosis was defined as an over 50% stenosis at follow up. No significant difference was detected with regard to global restenosis rate at an average of 4 months following implantation (Palmaz-Schatz 33%, Micro-Stent 27%). If results were analzyed according to implantation pressure however, there was a significantly lower restenosis rate for AVE Micro-Stens implanted with 〉 10 atm (17%) as compared to ≤ 10 atm (35%, p 〈 0.02) and as compared to Palmaz-Schatz-Stents (34%, p 〈 0.02), which were also implanted with high pressure over 10 atm. In addition to implantation pressure, vessel segment and morphology of stenosis proved to be important determinants of late results. In this series of patients the AVE-Micro-Stent compared favourably to the Palmaz-Schatz-Stent not only with respect to a significantly lower restenosis rate, when implanted with pressures 〉 10 atm, but also with regard to its superior flexibility and handling characteristics.
    Notes: Zusammenfassung Der Langzeiterfolg einer Stent-Implantation wird im wesentlichen durch die Restenoserate bestimmt. Bisher sind noch nicht alle Faktoren geklärt, welche die Restenoserate beeinflussen. Daher wurde in der vorliegenden Studie der Einfluß zweier unterschiedlicher Stentdesigns, der Implantationsart (Hochdruckimplantation 〉 10 atm, Niederdruckimplantation ≥ 10 atm), der Lokalisation der Stenose sowie der Stenose-Morphologie untersucht. Hierzu wurden die koronarangiographischen Untersuchungen von 259 Patienten, bei denen in 307 Stenosen insgesamt 196 Micro- und 142 Palmaz-Schatz-Stents implantiert worden waren, quantitativ vor, direkt nach und 3-6 Monate nach Stent-Implantation retrospektiv ausgewertet. Es fand sich zwischen den beiden Stent-Typen kein signifikanter Unterschied in der Restenoserate (Palmaz-Schatz 33%, Micro 27%). Bei Hochdruckimplantation des Micro-Stents mit Drucken von 〉 10 atm zeigte sich jedoch eine signifikant niedrigere Restenoserate sowohl im Vergleich zu den mit niedrigen Drucken implantierten Micro-Stents (17% versus 35%, p 〈 0,02) als auch im Vergleich zu den nahezu ausnahmslos mit Hochdruck implantierten Palmaz-Schatz-Stents (17% versus 34%, p 〈 0,02). Lediglich 11 Palmaz-Schatz-Stents wurden mit einem Druck von ≥ 10 atm implantiert. Ein Grund hierfür war aus den Untersuchungsprotokollen retrospektiv nicht zu entnehmen. In der LAD lag die Restenoserate mit 39% signifikant höher als in der RCX (21%) und RCA (22%, p 〈 0,02). Bei komplexen Typ-C-Stenosen zeigt sich eine höhere Restenoserate (39%) als bei Typ-A- (17%) und Typ-B-Stenosen (26%, p 〈 0,05). Insgesamt zeigt diese Studie Vorteile für den mit Hochdruck implantierten AVE-Micro-Stent aufgrund seiner geringeren Restenoserate im Vergleich zum Palmaz-Schatz-Stent.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1912
    Keywords: Thromboxane A2 (TXA2) ; Prostacyclin (PGI2) ; Human platelets ; Bovine coronary artery ; Non-steroidal antiinflammatory drugs ; Prostaglandin-cyclooxygenase ; Bioassay ; RCS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The action of the non-steroidal antiinflammatory drugs indomethacin, tiaprofenic acid, diclofenac and meclofenamate on vascular and plateletcyclooxygenases was studied by measuring the arachidonic acid-induced thromboxane A2 (TXA2)-formation of washed human platelets and prostacyclin (PGI2)-formation of bovine coronary artery rings. TXA2 was bioassayed as RCS on rabbit aorta strips, PGI2 in terms of its antiaggregatory activity on ADP-induced aggregation of human platelet-rich plasma. All of the substances studied produced concentration-dependent inhibition of PGI2- and RCS-release. The IC50 [μM] in inhibition of RCS-formation was 0.019 for indomethacin, 0.070 for tiaprofenic acid but 44.9 for meclofenamate and 63.2 for diclofenac. The IC50 [μM] in inhibition of PGI2-release was 0.42 for diclofenac, 0.63 for indomethacin and 0.99 for tiaprofenic acid. The data suggest (1) high sensitivity of human platelet-cyclooxygenase against indomethacin and tiaprofenic acid, (2) different sequence of the substances studied in inhibiting arachidonic acid-induced TXA2- and PGI2-formation. The possible therapeutic value of selective inhibition of platelets and vascular cyclooxygenases in discussed.
    Type of Medium: Electronic Resource
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