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  • 1
    Electronic Resource
    Electronic Resource
    Broadband (1000 cm−1) multiplex CARS spectroscopy: Application to polarization sensitive and time-resolved measurements (1994)
    Springer
    Applied physics 59 (1994), S. 369-375 
    Details
    ISSN: 1432-0649
    Keywords: 42.65.Dr ; 82.80.Ch ; 78.47
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A multiplex CARS spectrometer based on a cw diode-pumpedQ-switched Nd: YLF laser, a broadband dye-laser and a multichannel spectrum detection system has been constructed. Excellent mode characteristics of the laser beams and high pulse repetition rate (2 kHz) have resulted in good signal-to-noise ratio achieved with a few seconds accumulation time. A 1000 cm−1 wide spectral range is covered in a single CARS spectrum with an expanded bandwidth of the dye laser. A thin-jet sampling method is used in order to avoid the phase-matching limitation. The efficient spectral intensity normalization by the reference (CCl4) nonresonant spectrum and subsequent computer fitting have been implemented. The performance of the system is demonstrated by two different experiments. First, the polarization sensitive measurements (PS-CARS) of cyclohexane show its potential for accurate Raman depolarization ratio determination and for detection of weak (overlapped) Raman bands. Second, the transient resonance CARS measurement of the lowest excited triplet state of all-trans retinal indicate its feasibility to time-resolved CARS spectroscopy of fluorescent excited states.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01081059
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The 4G/5G polymorphism of the plasminogen activator inhibitor-1 gene is associated with severe preeclampsia (2000)
    Springer
    Journal of human genetics 45 (2000), S. 138-141 
    Details
    ISSN: 1435-232X
    Keywords: Key words Preeclampsia ; Plasminogen activator inhibitor type 1 ; Gene ; Polymorphism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Preeclampsia is associated with thrombosis of the intervillous or spiral artery. A deletion/insertion polymorphism (4G or 5G) in the promoter of the plasminogen activator inhibitor type 1 (PAI-1) gene is suggested to be involved in regulating the synthesis of the inhibitor, 4G allele, being associated with the enhanced gene expression and plasma PAI-1 levels. We assessed the association between preeclampsia and the 4G/5G polymorphism of the PAI-1 gene in 115 preeclamptic patients, 210 pregnant controls, and 298 healthy volunteer controls. The frequency of the homozygotes for the 4G allele was significantly higher in the patients than in the control pregnant women (P = 0.04) or in the healthy volunteers (P = 0.02). The 4G allele frequency was also significantly higher in the patients than in the control group of pregnant women (P = 0.03) and in the healthy volunteers (P = 0.02). These results suggest that the presence of the 4G/4G genotype of the PAI-1 gene is one of the risk factors for preeclampsia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100380050200
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    Paper (German National Licenses)
    Fulltext
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