ISSN:
1420-9071
Keywords:
Key words. Sodium current availability and activation; patch clamp; rat ventricular cardiomyocytes.
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract. The coupling between steady-state activation and availability from inactivation was characterized for the cardiac Na+ channel. To evaluate this coupling, we plotted the relationship between the conductance and availability curve midpoint potentials measured in 92 rat ventricular cardiomyocytes and applied a correlation analysis. We found a high correlation between the midpoints (correlation coefficient = 0.86, slope = 0.95) within the availability midpoint potential range positive to -100 mV. In contrast, the midpoints were not correlated in the myocytes (37 of 92 cells) having mid point potential negative to -100 mV, indicating an uncoupling between activation and availability.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s000180050135
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