ISSN:
1420-9071
Keywords:
Key words. Trehalose 6,6′-dimycolate (TDM); cord factor; mycolic acid; granuloma formation; Mycobacterium; gas chromatography-mass spectrometry.
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract. We analyzed the mycolic acid composition of trehalose 6,6′-dimycolate (TDM) obtained from Mycobacterium, using thin layer chromatography, gas chromatography and gas chromatography-mass spectrometry. Utilizing TDM, whose structure was confirmed, granuloma formation in mice was investigated. All TDM used exhibited considerable granuloma formation activity in the lung and spleen. In particular, TDM from M. bovis showed the greatest activity and toxicity among mycobacterial TDM. We therefore discussed the relationship between the chemical structure and granuloma-forming activity of TDM, especially in relation to the structure of mycolic acid in TDM.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/PL00000595
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