ISSN:
1438-2199
Schlagwort(e):
Keywords: Amino acids – Homocysteine – Vitamin B12 – Vitamin B6 – Folates – Coronary artery disease
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary. Homocysteine and vitamins B were correlated with coronary artery disease in patients undergoing diagnostic coronary angiography. 160 patients having ≧1 stenosis (G1), 55 patients having normal coronary arteries (G2) and 171 healthy volunteers (G3) were prospectively recruited. Homocysteine levels were significantly higher in patients, particulary in those with normal coronary angiograms, than in healthy subjects (13.8 ± 6.3 μmol/L in G1 (p 〈 0.0001) and 15.2 ± 8.8 μmol/L in G2 (p 〈 0.0001) versus 10.1 ± 3.1 μmol/L in G3). Homocysteine levels were not related to the extent of coronary artery disease. In patients with normal angiogram, vitamin B12 and folate levels were significantly higher compared with the other groups (p 〈 0.05 and p 〈 0.001, respectively) showing that vitamin B deficiency was not involved in the hyperhomocysteinemia. In conclusion, homocysteine and vitamins B levels do not contribute to discriminate for the presence of coronary artery disease in patients undergoing diagnostic coronary angiography. Homocysteine levels, however, were higher in patients referred for coronary angiography than in healthy controls.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/s007260050012
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