ISSN:
1573-7276
Keywords:
Keywords
;
colon 26
;
5¢-DFUR
;
hepatic metastasis
;
UFT
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The effects of fluorinated pyrimidines, 5¢-DFUR, UFT and T-506, on a mouse model of hepatic metastasis were assessed in regard to inhibitory activity and adverse reactions at the maximum tolerated dose. The model was prepared by injecting the mouse colonic cancer cell line, colon 26, into the portal vein of CDF1 mice. At the treatment regimens employed for 5¢-DFUR (1.0mmol/kg/day, p.o., daily from days 1 to 7), UFT (0.1mmol/kg/day, p.o., daily from days 1 to 7), and T-506 (0.074mmol/kg/day, i.v., days 1, 4, 7, and 10), complete inhibition of hepatic metastasis was obtained in six out of seven mice (85.7%) with 5¢-DFUR, and in five out of six mice (83.3%) with T-506. Significant inhibition of hepatic metastasis was not achieved with UFT (3/7, 42.9%). 5¢-DFUR and T-506 showed the highest rate of inhibition of hepatic metastasis, suggesting that these drugs would be effective for the prophylactic treatment of metastatic disease. 5¢-DFUR and UFT exhibited mild adverse reactions such as loss of body weight.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1018425532296
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