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  • Dinoflagellate Phylogeny  (1)
  • Keywords Verapamil  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Dinoflagellate ribosomal RNA; an evolutionary relic? (1975)
    Springer
    Journal of molecular evolution 5 (1975), S. 307-313 
    Details
    ISSN: 1432-1432
    Keywords: rRNA Evolution ; Dinoflagellate Phylogeny ; Dinoflagellate rRNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The apparent molecular weights of the rRNA subunits of the dinoflagellatePeridinium cinctum fa.westii were determined by polyacrylamide gel electrophoresis to obtain an indication of its evolutionary status. The apparent molecular weights of thePeridinium light and heavy rRNA subunits were 0.7 and 1.23 × 106 respectively. The light rRNA is therefore typically eukaryotic but the heavy rRNA has a significantly lower MW than previously reported for higher eukaryotes which range from 1.3 to 1.75 × 106 depending on their evolutionary position. Thus by this criterionPeridinium is similar to red algae and may represent a eukaryotic stage, lower than fungi or green plants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01732217
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    The effect of grapefruit juice on the pharmacokinetics of orally administered verapamil (1998)
    Springer
    European journal of clinical pharmacology 54 (1998), S. 337-340 
    Details
    ISSN: 1432-1041
    Keywords: Keywords Verapamil ; Grapefruit juice ; Pharmacokinetics ; Hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: To investigate the effect of grapefruit juice (GJ) on the pharmacokinetics of orally administered verapamil in hypertensive patients. Methods: Ten hypertensive patients on chronic verapamil treatment participated in a two-day study. On day 1 200 ml of water was given 1 hour before, and together with the morning verapamil dose; on the day 2, water was replaced by GJ in the same order. Serial blood samples were collected and the concentrations of verapamil and its main dealkylated metabolite (D-617) were determined by high-performance liquid chromatography (HPLC). The area under the concentration versus time curve of verapamil (AUCv) and its metabolite D-617 (AUCM) were calculated before and after GJ ingestion. The peak serum concentration (Cmax) and the time until its appearance (tmax) were also determined. Results: GJ did not affect Cmax, tmax, AUCv or AUVm. The AUCv/AUCm ratio (AUCR) was slightly, but significantly, increased after GJ (1.67 vs 1.92). Conclusions: A single administration of GJ with short-acting verapamil has no significant effect on the pharmacokinetics, of verapamil.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050470
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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