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Digitale Medien

Lissencephaly and pachygyria (1975)

Stewart, R. Malcolm ; Richman, David P. ; Caviness, Verne S.

Springer

Acta neuropathologica 31 (1975), S. 1-12

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Details

ISSN: 1432-0533

Schlagwort(e): Lissencephaly ; Pachygyria ; Neuronal Migration ; Laminar Necrosis ; Hypoxia ; Perfusion Failure

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary The architectonic features of abnormal cerebral cortex in a brain with lissencephaly and pachygyria suggest than neuronal migration was interrupted by cortical and subcortical laminar necrosis in the fourth fetal month. The severest cortical abnormality lies in the distal perfusion fields of the major cerebral arteries, while the normal areas are located in the proximal perfusion fields. These architectonic and topographic features suggest that intra-uterine hypoxia or perfusion failure may be a pathogenetic mechanism leading to lissencephaly and pachygyria.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00696881

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