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  • 1
    Electronic Resource
    Electronic Resource
    New chemotherapeutics in malignant mesothelioma: effects on cell growth and IL-6 production (2000)
    Springer
    Cancer chemotherapy and pharmacology 45 (2000), S. 502-508 
    Details
    ISSN: 1432-0843
    Keywords: Key words Malignant mesothelioma ; Chemotherapy ; Gemcitabine ; Irinotecan ; Interleukin-6
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: The benefits of chemotherapy can be assessed in terms of tumour shrinkage, prolongation of life or simply palliation of symptoms. In the study reported here, in vitro correlates of these parameters were sought as a rational guide to the choice of newer agents in the clinic. Methods: The cytotoxicity and effects on IL-6 production of ten chemotherapy agents representing four different classes of drugs were tested against a panel of five mesothelioma cell lines. Results: The mesothelioma cells were more sensitive to the action of irinotecan (and its active metabolite SN38) and gemcitabine than the control cell lines. Gemcitabine and to a lesser extent irinotecan inhibited the secretion of the proinflammatory cytokine IL-6 at concentrations of each drug that produced only small decreases in cell viability. This effect was not seen in cells treated with docetaxel or vindesine. Higher doses of gemcitabine and irinotecan caused a surge in IL-6 release and this was not due to release of intracellular stores of IL-6 through lysis of the cells. Conclusions: These results suggest that irinotecan and gemcitabine are not only more likely to be active against mesothelioma than other new chemotherapy agents but may also produce a palliative effect in nonresponders to these agents by decreasing the secretion of IL-6.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002800051026
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Laryngeal electromyography (1989)
    Springer
    European archives of oto-rhino-laryngology and head & neck 246 (1989), S. 395-396 
    Details
    ISSN: 1434-4726
    Keywords: Larynx ; Electromyography ; Technique ; Applications
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Over the last 40 years sporadic reports have appeared in the otolaryngological and neurological literature describing techniques and applications of laryngeal electromyography. Despite considerable refinements in methodology and instrumentation over that time laryngeal electromyography has not been widely adopted in routine clinical practice. This paper describes a simple, reliable and reproducible technique which has been employed by the author over a 15-year period. The indications for laryngeal electromyography are reviewed and the technique currently used is briefly described with reference to alternative techniques. The usefulness of the information obtained by this examination is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00463604
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    Paper (German National Licenses)
    Fulltext
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