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Development of velvet coat (Ve/Ve), another early lethal mutation in the house mouse (1979)

Granholm, Nels H. ; Stevens, Leroy C. ; Theiler, Karl

Springer

Anatomy and embryology 157 (1979), S. 237-242

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ISSN: 1432-0568

Keywords: Velvet coat ; Lethal ; Mouse ; ICM

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary A new semidominant mutation in the house mouse, velvet coat (Ve), is described. Ve homozygotes, recognizable on day 5 of gestation by their deficiency of ectodermal cells, never produce mesoderm and are resorbed by days 9–10. Primary Ve action may occur during the formation of the blastocyst or during determination and differentiation of the inner cell mass, or both. Accordingly, Ve/Ve embryos may provide a useful model for investigating primary gene action during blastocyst formation and subsequent differentiation.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00305164

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