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Paradoxical effects of low doses of d-amphetamine in rats (1971)

Glick, Stanley D. ; Muller, Robert U.

Springer

Psychopharmacology 22 (1971), S. 396-402

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ISSN: 1432-2072

Keywords: d-Amphetamine ; Lever Pressing ; Food and Water Intake

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Two experiments were conducted to examine the behavioral effects of low doses of d-amphetamine in rats. In contrast to previous studies showing depression of fixed-ratio 30 lever pressing by doses of d-amphetamine greater than 0.5 mg/kg, lower doses of the drug were found to facilitate such lever pressing. A low dose (0.05 mg/kg) of d-amphetamine was also found to enhance the amount of prandial drinking following food deprivation. These results indicated that the dose-response curve for d-amphetamine is generally non-monotonic and usually in the shape of an inverted U.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00406877

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