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Calcium sensitivity and unloaded shortening velocity of hypertrophied and non-hypertrophied skinned human atrial fibres (1989)

Arndt, H. ; Bletz, C. ; Katus, H. A. ; [et al.]

Springer

Pflügers Archiv 415 (1989), S. 209-213

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ISSN: 1432-2013

Keywords: Human atria ; Cardiac hypertrophy ; Skinned fibres ; Ca-sensitivity ; Shortening velocity

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract The mechanical properties of myocardium of different animals are modified by a chronic increase in haemodynamic load. In this study differences in calcium sensitivity and maximum unloaded shortening velocity of hypertrophic and non-hypertrophic chemically skinned human atrial fibres are characterized. Investigating right atria of 34 patients, possible correlations are studied between preoperative atrial pressure, degree of hypertrophy (estimated from the muscle fibre diameter), calcium responsiveness (pCa50 eliciting half-maximum contraction) and V max (unloaded shortening velocity). Hypertrophic fibres from atrial appendages of patients having an increased right atrial pressure (RAP 8.5±1.6 mm Hg) and suffering from mitral valve disease (stenosis and insufficiency combined) had a fibre diameter of 18.0±0.9 μm. They also had a higher calcium sensitivity (pCa50 5.65±0.08) and a lower unloaded shortening velocity (1.7±0.1 muscle lengths/s) than non-hypertrophic fibres from the appendages of patients with normal right atrial pressure (RAP 3.2±0.5 mm Hg) and coronary heart disease (CHD: pCa50 5.45±0.04; V max= 3.4±0.2 muscle lengths/s; fibre diameter 12.8±0.4 μm). Thus non-hypertrophic fibres from control CHD patients differed significantly (p 〈 0.01) from hypertrophied atrial fibres of patients with mitral valve disease and with combined valve disease (MAV, pCa50=5.58±0.05, V max 2.0±0.3 muscle lengths/s, fibre diameter 14.6±0.9 μm) or aortic valve disease (stenosis combined with insufficiency, fibre diameter 14.8±1.4 μm, pCa50 5.56±0.03, V max 2.0±0.24 muscle lengths/s; RAP 11.0±2.6 mm Hg). Such alterations of calcium responsiveness, shortening velocity and fibre thickness may reflect an adaptation to the chronic overload in atria from patients with various forms of heart valve disease.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00370594

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Zu Problemen der Photosynthesemessungen bei der Kultivierung von Mikroalgen (1985)

Arndt, H. ; Tschirner, E. ; Böhm, H.

Berlin : Wiley-Blackwell

Acta Biotechnologica 5 (1985), S. 35-44

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ISSN: 0138-4988

Keywords: Life Sciences ; Life Sciences (general)

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Process Engineering, Biotechnology, Nutrition Technology

Notes: The rate of photosynthetic activity of a single alga cell, their variability in the course of individual life, the time dependence of conditional influences, the dependence of the action of the condition on the registered parameter are shown by results of our measurements. The further underline the necessity of parallel short- or longtime measurements with several charges. Under these conditions, techniques on the basis of gasanalysers are profitable for the planning of measuring systems for photosynthesis with the ability to continuous, simulataneous in vivo measurements of photosynthetic rates of O2-output and CO2-fixation in open gas-stream with parallel charges. A measuring system, which meets these requirements, is demonstrated.

Additional Material: 7 Ill.