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Effect of glicentin-related peptides on glucagon secretion in anaesthetized dogs (1986)

Ohneda, A. ; Kobayashi, T. ; Nihei, J.

Springer

Diabetologia 29 (1986), S. 397-401

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ISSN: 1432-0428

Keywords: GLI ; glicentin-related peptide ; glucagon ; insulin ; dog pancreas

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Recent studies have demonstrated that glicentin is released during nutrient ingestion. However, the biological function of glicentin remains unclear. In order to clarify the role of glicentin in the enteroinsular axis, the effect of glicentin-related peptides was investigated using in vivo local circulation of canine pancreas. Peaks I and II of gut glucagon-like immunoreactivity, partially purified from porcine intestinal extract by affinity chromatography and gel filtration, synthesized hexadecapeptide of N-terminal glicentin (1–16) and synthesized octapeptide of C-terminal glicentin (62–69) were administered for 10 min into the pancreaticoduodenal artery of canine pancreas. Blood samples were then drawn from the pancreaticoduodenal vein. The administration of peak I of glucagon-like immunoreactivity during arginine infusion in a dosage of 20 ng reduced the glucagon secretion by 42 pmol/1 (p〈0.05), whereas peak 11 of glucagon-like immunoreactivity (20 ng) slightly increased the plasma level of insulin, although not significantly. The administration of glicentin (1–16) in a dosage of 400 ng during saline infusion did not alter the plasma insulin level, but reduced the plasma glucagon level in the pancreaticoduodenal vein by 29 pmol/1 (p〈0.05). In addition, glicentin [62–691 in a dosage of 400 ng exerted a decrease in both the plasma insulin (40 mU/1,p〈0.05) and glucagon level (27 pmol/l,p〈0.05). The present study demonstrates the suppression of pancreatic glucagon release during the infusion of peak I glucagon-like immunoreactivity and N- or C-terminal glicentin-related peptide. Therefore, it is suggested that glicentin released during nutrient intake might inhibit the secretion of glucagon.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00903352

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Response of sensory receptors of the cat's hindlimb to a transient, step-function DC electric field (1986)

Kato, M. ; Ohta, S. ; Kobayashi, T. ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Bioelectromagnetics 7 (1986), S. 395-404

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ISSN: 0197-8462

Keywords: hair receptors ; afferent impulses ; neurophysiology ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Physics

Notes: There are two possible mechanisms of effects of large electric fields on animals, one caused by the electric field at the body surface and the other caused by the electric current induced inside the body. The purpose of the present experiments was to investigate the former possibility by recording action potentials from afferent fibers innervating various sensory receptors in the cat's hindlimb. Cat hairs were attracted to the upper electrode when exposed to DC electric fields of 180 kV/m or greater, and action potentials were evoked in the afferent fibers innervating G1, G2, and down hair receptors. No action potentials were evoked in afferent fibers innervating type I, type II, field receptors, muscle spindles, or joint receptors. These results indicate that a strong DC electric field induced movement of the hairs, eventually evoked excitation of the hair receptors, but that other receptors located under the skin were not influenced by electric field exposure.

Additional Material: 8 Ill.