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  • Analytical Chemistry and Spectroscopy  (12)
  • Inguinal hernia  (2)
  • Life and Medical Sciences  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Prospective double-blind randomized study comparing Perfix® plug-and-patch with Lichtenstein patch in inguinal hernia repair: one year quality of life results (2000)
    Springer
    Hernia 4 (2000), S. 255-258 
    Details
    ISSN: 1248-9204
    Keywords: Inguinal hernia ; Plug ; Mesh ; Groin pain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Background The 14 day results of this study reported elsewhere demonstrated that the Perfix® plug-and-patch was as effective as the Lichtenstein patch but not as cost-effective. The present analysis looks at the results at one year to measure quality of life between the two groups. Patients and Methods 141 patients were randomly allocated in a doubleblind manner to receive either a Lichtenstein patch (patch) or a Perfix® plug- and-patch (plug-and-patch) for primary inguinal hernia. Quality of life at 6 months and one year was assessed by the short-form 36 (SF36). On a 3 point scale patients were asked at one year to rate groin, wound and testicular discomfort. Results Physical function by SF36 was similar in the 2 groups at 6 months, but at one year in the patch group (95.11 +/-20.07) was significantly better (p 〈 0.05) than physical function in the plug-and-patch group (82.5 ± 20.98). At one year the number of patients with wound discomfort limiting work or social activities was significantly greater in patients receiving the plug-and-patch (n = 12) compared with patients receiving the patch (n = 4), p 〈 0.031. At one year, 4 of 70 patients receiving the plug-and-patch had required reoperation to remove the preformed plug-and-patch device and replace it with a flat Lichtenstein patch, because of wound pain which was limiting activity. Conclusion A significant proportion of patients suffer chronic pain after placement of a Perfix® plug-and-patch for primary inguinal hernia repair. Removal of the Perfix® device is required in approximately i in 20 patients (5.6% in this series).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01201078
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  • 2
    Electronic Resource
    Electronic Resource
    The benefits of a hernia service in a public hospital (2000)
    Springer
    Hernia 4 (2000), S. 1-5 
    Details
    ISSN: 1248-9204
    Keywords: Inguinal hernia ; Daycase ; Ambulatory ; Cost-savings
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A Hernia Service (HS) was commenced in Derriford Hospital, Plymouth, UK in May 1996 to improve patient outcome following a poor star rating for overall hospital performance in daycase hernia surgery. Between 1996 and December 1998, 576 patients, median age 65 years (range 24–88) with unilateral or bilateral inguinal hernias underwent surgical repair on the HS. During the same time period on the General Surgical Service (GSS) 1722 patients underwent surgical repair. On the HS, patients operated under local anaesthesia (LA) increased from 78.0 to 90.5%, and on the GSS use of LA increased from 7.6 to 22.4%. The percentage of daycases on the HS increased from 53.0 to 81.4% and on the GSS from 2.9 to 28.0%. The actual number of inpatient hospital days saved by the HS was 236 days in 1997 and 284 days in 1998. The potential saving was greater: in 1998 if the GSS daycase rate (28.0%) had been the same as the HS daycase rate (81.4%) 605 inpatient days would have been saved. A hernia satisfaction questionnaire was sent to a ran dom sample of 50 patients who had had their hernia repaired by the HS and 50 patients who had been treated by the GSS. HS patients experienced a mean pain score of 4,7 (range 1–10) compared to 5.7 (range 0–10) (p=0.07) for the GSS. Similarly, HS patients required less post-operative analgesia (mean 2.8 days compared to 5.9 days for the GSS group, p〈0.01) and resumed normal activity at an earlier stage (mean 10.8 days compared to 17.6 days for the GSS patients, p〈0.01). Instigation of a dedicated HS has improved patient outcome and substantially increased the use of local anaesthesia and the number of daycase hernia repairs on both the HS and the GSS, with substantial cost savings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01230579
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  • 3
    Electronic Resource
    Electronic Resource
    Identification and confirmation of arsenobetaine and arsenocholine in fish, lobster and shrimp by a combination of fast atom bombardment and tandem mass spectrometry (1987)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 14 (1987), S. 723-732 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Using fast atom bombardment (FAB) ionization combined with tandem mass spectrometry (MS/MS), the identity of arsenobetaine (AB) in extracts of sole, haddock, lobster and shrimp was unequivocally confirmed. Evidence was also presented for the presence of arsenocholine (AC) in the shrimp extract. Confirmation was obtained by comparing the collision-induced dissociation (CID) daughter ion and parent ion spectra of major ions in the FAB spectra from these extracts with those from the authentic standards.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200141206
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  • 4
    Electronic Resource
    Electronic Resource
    Capillary column gas chromatography/tandem mass spectrometry verification of chemical warfare agents (1992)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 6 (1992), S. 717-718 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Chemical weapons use, although prohibited by the 1925 Geneva Protocol, has been reported in several armed conflicts including the Iran/Iraq war. The use of these weapons during this conflict and the concern over possible use of chemical warfare (CW) agents during the Persian Gulf war has heightened international awareness and prompted many nations to pursue with incresed vigour the signature of a new Chemical Weapons Convention. The most recent draft of the Chemical Weapons Convention contains a number of provisions aimed at developing a treaty that will enable nations to ensure compliance by all signatory nations. Compliance monitoring will be required in a number of scenarios, including the verification of alleged use, the storage and destruction of chemical weapons stocks and ensuring that industrial sites are not illegally producing CW agents. It follows from this draft treaty that compliance monitoring will require a high level of sophisticated analytical support to ensure the establishment of an enforceable treaty. The United Nations Conference on Disarmament therefore formed a multi-national Technical Group on Instrumentation to address the analytical challenges confronting signatory nations.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290061117
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  • 5
    Electronic Resource
    Electronic Resource
    Investigation of products arising from enzymatic digestion of advanced glycated albumin by high-performance liquid chromatography/mass spectrometry (1991)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 5 (1991), S. 624-628 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: The structural investigation of the products arising from 28 days incubation of albumin with high glucose concentration and further enzymatic hydrolysis has been carried out by means of high-performance liquid chromatography/mass spectrometry (HPLC/MS) under plasmaspray conditions. By this approach many different compounds have been detected, and for most of them, possible structures have been proposed on the basis of literature data and molecular weight assignments.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290051212
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  • 6
    Electronic Resource
    Electronic Resource
    Regulation of polyamine transport by polyamines and polyamine analogs (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 155 (1993), S. 399-407 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Regulation of polyamine transport in murine L1210 leukemia cells was characterized in order to better understand its relationship to specific intracellular polyamines and their analogs and to quantitate the sensitivity by which it is controlled. Up-regulation of polyamine uptake was evaluated following a 48-hr treatment with a combination of biosynthetic enzyme inhibitors to deplete intracellular polyamine pools. The latter declined gradually over 48 hr and was accompanied by a steady increase in spermidine (SPD) and spermine (SPM) transport as indicated by rises in Vmax to levels ∼4.5 times higher than control values. Restoration of individual polyamine pools during a 6-hr period following inhibitor treatment revealed that SPD and SPM uptake could not be selectively affected by specific pool changes. The effectiveness of individual polyamines in reversing inhibitor-induced stimulation of uptake was as follows: putrescine 〈 SPD 〈 SPM = the SPM analog, N1, N12-bis(ethyl)spermine (BESPM). In contrast to stimulation of transport, down-regulation by exogenous polyamines or analogs occurred rapidly and in response to subtle increases in intracellular pools. Following a 1-hr exposure to 10 μM BESPM, Vmax values for SPD and SPM fell by 70%, whereas the analog pool increased to only 400-500 pmol/106 cells - about 15-20% of the total polyamine pool (∼2.8 nmol/106 cells). SPM produced nearly identical regulatory effects on transport kinetics. Both BESPM and SPM were even more effective at down-regulating transport that had been previously stimulated four to fivefold by polyamine depletion achieved with enzyme inhibitors. A dose response with BESPM at 48 hr revealed a biphasic effect on uptake whereby concentrations of analog 〈 3 μM produced an increase in SPD and SPM Vmax values, whereas concentrations 3 μM and higher produced a marked suppression of these values. Cells treated with 3 μM BESPM for 2 hr and placed in analog-free medium recovered transport capability in only 3 hr. Thus, whereas stimulation of polyamine transport is a relatively insensitive and slowly responsive process that tends to parallel polyamine depletion, down-regulation of polyamine transport by exogenous polyamines and analogs and its reversal are rapidly responsive events that correlate with relatively small (i.e., 15-20%) changes in intracellular polyamine pools.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041550222
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    A novel mass marker for metastable ion scans in a double focusing mass spectrometer (1980)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1980), S. 564-567 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Characterization and assignment of the products of metastable decompositions which are transmitted by a double focusing mass spectrometer, is often complicated by the inability to measure precisely the parent/daughter ion mass values directly from the spectra which appear on chart paper. This is often because there are considerably fewer peaks in these types of spectra compared with a normal mass spectrum obtained from high energy reactions in the ion source. Electronic circuits are described which permit accurate parent/daughter ion mass values to be obtained when the products of metastable decompositions are transmitted through the ZAB-2F double focusing mass spectrometer. Digital logic circuitry is also described which is used to mark mass values during a scan by driving either a solenoid pen drive unit for a chart recorder or a galvanometer on a multi-range ultraviolet oscillograph recorder.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210151104
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  • 8
    Electronic Resource
    Electronic Resource
    Charge stripping reactions of ions formed from methane, ammonia, water and hydrogen sulphide by protonation and by electron impact (1981)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 16 (1981), S. 454-458 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The minimum energy, Qmin, necessary to convert an ion m1+ to a doubly charged ion m12+ is obtained for 19 different ions from methane, ammonia, water and hydrogen sulphide by charge stripping using nitrogen collision gas. The ions studied include the [MH]+ ions formed by chemical ionization in a high pressure source. Stable m12+ ions could not be formed in the case of [NH4]+, [NH]+·, [H2O]+· and [OH]+. Even in these cases the value of Qmin could be estimated by studying the fragments formed from the unstable m2+ ions. In several cases, the energy required to form m12+ ions is less than the literature value for the ionization energy of m1+. This is discussed in terms of the possibility of the presence of excited states of m1+ in the present experiments.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210161008
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  • 9
    Electronic Resource
    Electronic Resource
    The elimination of carbon monoxide from molecular ions of phenol and other [C6H6O]+· isomers (1982)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 17 (1982), S. 81-85 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Phenol and five acyclic isomeric compounds have been investigated using electron impact and field ionization techniques, mass analysed ion kinetic energy spectrometry and collision induced dissociation mass analysed ion kinetic energy spectrometry. The kinetic energy release data corresponding to the elimination of carbon monoxide from the molecular ions show that at least two structures of the reactant ion are involved. The electron impact and field ionization collision induced dissociation mass analysed ion kinetic energy spectra indicate that under electron impact conditions, the phenol ion partially isomerizes to another ion structure. An isomerization of about 40% to the structure of cis-2-hexen-4-yn-1-al is in good accordance with the spectral data.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210170206
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  • 10
    Electronic Resource
    Electronic Resource
    The modern mass spectrometer - a complete chemical laboratory (1981)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 16 (1981), S. 101-114 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Using nitrobenzene as an example, various ways in which a contemporary mass spectrometer can be utilized to yield a wealth of information about the compound studied are reviewed. Applying a variety of different techniques and procedures, in addition to the conventional low resolution mass spectrum, the following nitrobenzene spectra have been obtained: collision induced dissociation mass spectrum, mass analysed ion kinetic energy spectra, collision induced dissociation mass analysed ion kinetic energy spectra, spectra obtained at constant B/E, spectra obtained at constant B2/E, high voltage scans of metastable ion fragmentation processes, consecutive fragmentations in different field free regions, charge exchange mass spectra, charge stripping mass spectra, doubly charged ion mass spectra, chemical ionization mass spectra, negative ion mass spectra, negative ion mass analysed ion kinetic energy spectra, negative ion mass analysed ion kinetic energy collision induced dissociation spectra, charge inversion spectra, etc. The complementary types of information available from the above studies are discussed to show the unique versatility of mass spectrometry as a technique for the examination of organic compounds.
    Additional Material: 32 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210160302
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