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Distributions of p53 codon 72 polymorphism in bladder cancer – proline form is prominent in invasive tumor (2000)

Chen, W.-C. ; Tsai, F.-J. ; Wu, J.-Y. ; [et al.]

Springer

Urological research 28 (2000), S. 293-296

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ISSN: 1434-0879

Keywords: Key words p53 codon 72 polymorphism ; Bladder cancer ; Proline form ; Arginine form

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Abnormal function of p53 is commonly associated with various cancer formations. High-grade and late-stage bladder cancers have been reported to have mutated or become inactive p53 when using immunohistochemical stains. Recently, p53 codon 72 polymorphism was extensively studied to determine the risk factors responsible for cancer formation. There was a general population of codon 72 sequence polymorphism of the wild type p53. A single base change from G to C caused the alteration of amino acid residue 72 from arginine to proline. The arginine form is considered to be a significant risk factor in the development of cancer. However, various reports had indicated discrepancies with regard to this polymorphism; some showed no significant difference between the control and cancer groups, while other series were associated with high risks in the proline form homozygotes. To resolve the undefined distribution of this polymorphism in bladder cancers, 58 patients with bladder cancer were enrolled onto this study. When checked using the Chi-squared test (P=0.952) there were no differences between the control subjects and bladder cancer patients in the distribution of polymorphism. However, proline form homozygotes were more frequently found in the invasive group than the non-invasive group by Fisher's exact test (25% and 2.9%, respectively, P 〈 0.001). More than 70% of the non-invasive bladder cancers were the arginine form homozygotes. This result is consistent with those reported for hepatocellular carcinoma that showed a history of chronic liver disease and proline form homozygotes in a report by Yu et al. Our data suggest that proline form homozygotes are associated with invasive bladder cancer.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s002400000117

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Evidence concerning the morphogenesis of saccular receptors in the bullfrog (Rana catesbeiana)Research sponsored by the Joint Services Electronics Program, Contract F44620-71-C-0087 and the United States Public Health Service, National Institute of Health, grant GM-17523-02. (1973)

Lewis, E. R. ; Li, C. W.

New York, NY : Wiley-Blackwell

Journal of Morphology 139 (1973), S. 351-361

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ISSN: 0362-2525

Keywords: Life and Medical Sciences ; Cell & Developmental Biology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Medicine

Notes: A dichotomy of hair-cell types has been found in the bullfrog sacculus, and considerable evidence supports the view that one type (“peripheral”) is transformed during macular growth to the other type (“central”). Between the periphery and the center of the macula, one finds a gradation of form from “peripheral” to “central” type. Occasionally in adults and more often in stage-26 tadpoles one finds the presumably younger peripheral type of hair cell occurring well beyond the limits of the macula proper. The apparent morphogenic sequence for saccular hair cells is (1) development of a kinocillum on an endolymphatic epithelial cell, (2) gradual transformation of microvilli into stereocilia, (3) growth of the stereocilia and development of kinociliary bulb, (4) achievement of final size and form.

Additional Material: 15 Ill.