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  • 1
    Electronic Resource
    Electronic Resource
    Lacticacidosis, neurological deterioration and compromised cellular pyruvate oxidation due to a defect in the reoxidation of cytoplasmically generated NADH (1983)
    Springer
    European journal of pediatrics 140 (1983), S. 98-101 
    Details
    ISSN: 1432-1076
    Keywords: Lacticacidosis ; Neurological deterioration ; Redox disequilibrium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two patients, one dying at 25 days and one at 20 months had ‘chronic’ lactic acidaemia with a high lactate to pyruvate ratio. Both showed EEG abnormalities and seizure activity and both died of respiratory failure. Investigation of cultured skin fibroblasts from these patients revealed normal pyruyate dehydrogenase and pyruvate carboxylase activities but the cells showed a decreased ability to oxidise pyruvate which was returned to normal on the addition of methylene blue. Subsequent investigations revealed that the mitochondria from the patients' cells could oxidise pyruvate normally but that the cells had an abnormal NAD to NADH ratio under standard conditions of incubation. It was concluded that both children had a redox disequilibrium in the cytoplasmic compartment due to a problem in transporting reducing equivalents from the cytoplasmic to the mitochondrial compartments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441651
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  • 2
    Electronic Resource
    Electronic Resource
    Fracture of long bones: Rate effects under singular and combined loading states (1983)
    Hoboken, NJ [u.a.] : Wiley-Blackwell
    Journal of Orthopaedic Research 1 (1983), S. 244-250 
    Details
    ISSN: 0736-0266
    Keywords: Fracture behavior ; Axial-torsional loading ; Life and Medical Sciences
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: This study was undertaken to determine the effect of loading rate on bone failure under singular and combined loading states. Using the entire loading range of an Instron Materials Testing Machine, 190 pairs of canine radii were tested. One bone of each pair was subjected to either torsional or a combination of axial and torsional loads, and compared with a control specimen. Compressive loads of 4.6 and 11.5 N were utilized. Torque to failure and energy data versus loading rate were plotted. As loading rate increased, the torque and energy values were found to increase, reach a peak, and then decline at higher rates. Fractures produced under the combined state of loading are representative of those clinically found in human trauma situations.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jor.1100010303
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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