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Characterization of the chromatin structure in the upstream region of the chicken alpha-globin gene domain (1994)

Razin, S. V. ; Moura Gallo, C. V. ; Scherrer, K.

Springer

Molecular genetics and genomics 242 (1994), S. 649-652

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ISSN: 1617-4623

Keywords: α-Globin domain ; Hypersensitive sites ; Locus control region ; Chromatin structure

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Abstract The distribution of DNase I hypersensitive sites upstream of the chicken α-globin gene cluster was studied. A group of hypersensitive sites with a complex pattern of tissue specificity, including erythroid-specific elements, was found at a distance of 11.5–14.5 kb upstream of the π gene, the first gene in the cluster. The observations indicate that this area, located upstream of the block of AT-rich sequences and MAR sites (at −8 kb) and upstream of the site of permanent DNA attachment to the nuclear matrix (−3 kb), still belongs to the domain of the α-globin genes.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00283418

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DNA interactions with the nuclear matrix and spatial organization of replication and transcription (1987)

Razin, S. V.

New York, NY : Wiley-Blackwell

BioEssays 6 (1987), S. 19-23

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ISSN: 0265-9247

Keywords: Life and Medical Sciences ; Cell & Developmental Biology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Medicine

Notes: Analysis of the DNA sequence associated with the nuclear matrix has made it possible to identify several types of DNA matrix association. Permanent attachment sites are detected in both transcriptionally active and inactive nuclei. Furthermore, replication origins have been shown to be permanently attached to the nuclear matrix. In transcriptionally active nuclei, expressed genes are also associated with the nuclear matrix. Finally, a special group of attachment sites is described; these sites are believed to maintain the fixed positions of individual chromosomes in interphase nuclei.

Additional Material: 2 Ill.