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  • 1
    Electronic Resource
    Electronic Resource
    The effect of hematoporphyrin and light on human plateletsThis investigation was supported by a research grant he 09102-02 from the national heart institute, bethesda, maryland.Presented in part at the meeting of the federation of american societies for experimental biology in april, 1964 and abstracted in fed. proc., 24: 519, 1965.. I. Morphologic, functional, and biochemical changes (1966)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 67 (1966), S. 271-279 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The morphologic, functional, and biochemical changes produced by hematoporphyrin and light in human platelets have been characterized. by phase microscopy the cells appeared swollen and resembled signet rings; by electron microscopy they showed considerable loss of cytoplasm and their contour was smoother than normal. irradiated platelets were not aggregable by thrombin and calcium chloride, although they contained clottable protein, and were incapable of supporting clot retraction. a linear relationship was demonstrated between the per cent depletion of serotonin from irradiated platelets and the log dose of hematoporphyrin. the depletion of serotonin from these platelets was related lineraly to the log of time of exposure to light during the initial six minutes of exposure; but thereafter continued at a constant rate. the temperature of incubation influenced directly the rate of depletion of serotonin from irradiated platelets but did not influence the movement of serotonin into these platelets. atp was diminished considerably in irradiated platelets. these changes are attributable to damage to the membrane of the platelet by hematoporphyrin and light.These studies provide additional information about the blood platelet in terms of its response to photodynamic action.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040670207
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of hematoporphyrin and light on human plateletsThis investigation was supported by a research grant he 09102-02 from the national heart institute, bethesda, maryland.Presented in part at the meeting of the federation of american societies for experimental biology in april, 1965 and abstracted in fed. proc., 24: 519, 1965.. II. Uptake of hematoporphyrin (1966)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 67 (1966), S. 281-284 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: A linear relationship was demonstrated between the reciprocals of the concentration of free hematoporphyrin and the moles of hematoporphyrin taken up by the platelet in the dark. radiated platelets took up more hematoporphyrin than did controls; this increase in uptake was accounted for by the movement of the dye across the damaged membrane of the cell. platelets irradiated at 4°c remained impermeable to hematoporphyrin until warmed to 37°c. during the initial three to four minutes of exposure to light at 37°c, there was no additional uptake of hematoporphyrin by platelets in comparison to controls. between six to ten minutes irradiation, the uptake of hematoporphyrin increased linearly with the log time of irradiation. thereafter, no further uptake occurred. a further increase in uptake of dye was demonstrated by both control and irradiated platelets at a reduced ph. this study enables a correlation to be made between the effects of hematoporphyrin on the platelet and the uptake of this agent by the platelet.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040670208
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The effect of hematoporphyrin and light on human platelets. III. Release of potassium and acid phosphatase (1966)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 68 (1966), S. 109-111 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Human platelets, exposed to hematoporphyrin and light, were depleted of potassium and acid phosphatase. A linear relationship was demonstrated between the per cent depletion of potassium from irradiated platelets and the log dose of hematoporphyrin. The initial release of potassium and acid phosphatase from irradiated platelets was first order. Rate constants demonstrated that potassium was released five times faster than acid phosphatase. At 4°C, release of both potassium and acid phosphatase was the same as at 37°C. These results are compared to previous data on the release of serotonin from irradiated platelets.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040680204
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Assessment of conduction properties and thermal noise in cell membranes by admittance spectroscopy (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Bioelectromagnetics 13 (1992), S. 87-100 
    Details
    ISSN: 0197-8462
    Keywords: membrane driving-point functions ; ion channels ; rapid admittance determinations ; channel conduction rate constants ; thermal noise ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Advances in the speed of signal processing enable application of a Fourier-synthesized function as a small perturbation (1 mV) superposed on voltage clamp steps to rapidly (〈1 sec) acquire cell membrane complex driving-point functions (impedance or admittance) in several frequency bands ranging from 1 Hz to 10 kHz. Curve fits of admittance models to these data yield a complete quantitative linear description of membrane conduction systems and their kinetics. Furthermore, the rate constants between microscopic states of an ion channel can be calculated from conductance parameters derived from model curve fits of membrane admittances. Additionally, the power spectrum of membrane thermal noise is obtainable from impedance determinations by use of the Nyquist relation. Consequently, rapid driving-point function determinations provide the most complete macroscopic assessment of membrane conduction properties presently available. Admittance determinations of the potassium conduction system in squid giant axon and the potassium conducting “inward rectifier” in snail neuron are used to illustrate the above points. 1992 Wiley-Liss, Inc.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bem.2250130709
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    Paper (German National Licenses)
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