ISSN:
1432-1106
Keywords:
Nerve
;
Limb
;
Transplant
;
Salamander
;
Neuropharmacology
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Pharmacological, electrophysiological, and histological studies have been performed on a nerve-limb deplant in the dorsal limb of the axolotl salamander. The preparation, which consists of a limb and a segment of spinal cord transplanted contiguously in a host salamander, exhibits spontaneous electrical and contractile activity a few weeks after transplantation. By electromyographic recording it has been possible to study the response of the preparation to a variety of transmitter substances and neuropharmacological agents and to determine their locus of action on the preparation. Cholinoceptive regions appear to be present at the myoneural junction as well as in the innervating neurons. Glutamic acid has an excitatory and γ-aminobutyric acid an inhibitory effect on the neuronal cell bodies. The preparation offers a unique opportunity to investigate developmental, neurochemical, and functional correlations in the nervous system.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00239163
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