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  • 1
    Electronic Resource
    Electronic Resource
    Neuronal lesions in mercaptopropionic acid-induced status epilepticus (1988)
    Springer
    Acta neuropathologica 77 (1988), S. 47-54 
    Details
    ISSN: 1432-0533
    Keywords: Status epilepticus ; Substantia nigra ; Pathology ; Convulsions ; Convulsants
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neuropathological studies of rats were made after seizures of different durations. Seizures were produced by mercaptopropionic acid in paralyzed, ventilated rats that were perfusion-fixed immediately (acute) or after 2–7 days of recovery (chronic). Analysis of chronic rats, which had only 20-min seizures, showed that damage occurred to several structures including: the substantia nigra pars reticulata, the hypothalamus, the diagonal band of Broca, and the globus pallidus; the damage was worse with longer seizures. In rats perfused acutely no changes were detected in paraffin sections in the aforementioned structures if the length of seizures was 45 min or less. It was concluded that: (1) mercaptopropionic acid-induced seizures cause permanent lesions to specific brain areas, with the most pronounced effect in the substantia nigra pars reticulata; (2) the lesions result from the seizures, and they are roughly proportional to the seizures duration; and (3) permanent lesions may begin within 20 min but require longer times to become visible on light microscopy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688242
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Substantia nigra lesions in mercaptopropionic acid induced status epilepticus: a light and electron microscopic study (1989)
    Springer
    Acta neuropathologica 77 (1989), S. 612-620 
    Details
    ISSN: 1432-0533
    Keywords: Status epilepticus ; Substantia nigra ; Pathology ; Convulsions ; Convulsants
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Light microscopic and ultrastructural changes of substantia nigra were studied in paralyzed ventilated rats with status epilepticus induced by mercaptopropionic acid. Some rats were killed at the end of seizure activity and others were examined in varying intervals after the arrest of seizure. The earliest changes were reduction in the size of the neuronal nuclei and chromatin clumping followed by simultaneous distention of axons and dendrites. There was also enlargement of the neuronal perikarya associated with microvacuolation. This neuronal microvacuolation corresponded ultrastructurally to swollen mitochondria with disrupted cristae. These changes were followed by progressive neuronal shrinkage and astrocytic swelling. The swollen astrocytic processes together with swollen neurites gave a spongy appearance to the involved area. The lesion thereafter progressively enlarged and evolved into an area of frank necrosis containing abundant macrophages. This lesion is morphologically different from that produced in cortex and hippocampus by seizure activity or due to the direct effect of excitotoxins. The significance of substantia nigra pars reticularis changes and their pathogenesis are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687889
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Numerical model of deep venous thrombosis detection using venous occlusion strain gauge plethysmography (2000)
    Springer
    Medical & biological engineering & computing 38 (2000), S. 348-355 
    Details
    ISSN: 1741-0444
    Keywords: Deep venous thrombosis ; Venous occlusion plethysmography ; Limb blood flow ; Theoretical model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Strain gauge plethysmography (SGP) is a non-invasive method used in the detection of deep venous thrombosis (DVT). The technique is based on the measurement of calf volume changes in response to venous occlusion by a thigh cuff, the volume changes reflecting the rates of arterial inflow and venous outflow. A numerical model of the blood circulation within the limb and the response of this to a SGP test has been derived, based on treating the different parts of the circulatory system in the leg as resistance and capacitance elements. The simulation results were compared with clinical studies and support the ability of SGP to detect non-occlusive clots of more than 50–60% of the lumen, as well detecting calf vein pressure appears to be a particularly important factor within the model. In addition, increases in venous tone due to post-operative venospasm were shown to be a potential source of false positive results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02347057
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    Paper (German National Licenses)
    Fulltext
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