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  • 1
    Digitale Medien
    Digitale Medien
    The effect of lithium chloride administration on brain and heart norepinephrine turnover rates (1969)
    Springer
    Psychopharmacology 14 (1969), S. 315-322 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Lithium ; Norepinephrine ; Kinetics ; Brain Chemistry ; Manic-Depressive Psychoses
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The effect of Li+ on NE turnover rates in rat heart and brain was studied. Turnover rates were determined in brain and heart by blocking tyrosine hydroxylase with L-α-methyltyrosine and following the decline of NE with time or in heart by injecting3H-NE and following the decline of NE specific activity with time. Subacute treatment with LiCl in doses that maintained a serum lithium level within the clinically therapeutic range caused: 1. A 95% increase in brain NE turnover rate without altering the steady-state level of the amine. 2. A slight but not significant increase in heart NE turnover. 3. The selective increase in brain NE turnover, compared to heart, may be attributed to the higher tissue levels of Li+ found in the brain under the conditions of study.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02190116
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  • 2
    Digitale Medien
    Digitale Medien
    Modulation of muscarinic receptor-mediated adenylate cyclase and phospholipase C responses in rat retina (1991)
    Springer
    Cellular and molecular neurobiology 11 (1991), S. 455-462 
    Details
    ISSN: 1573-6830
    Schlagwort(e): muscarinic receptors ; adenylate cyclase ; cyclic AMP ; phosphoinositide hydrolysis ; phorbol esters ; pertussis toxin ; cholera toxin ; rat retina
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary 1. Agonist activation of rat retina muscarinic receptors results in suppression of cyclic AMP (cAMP) generation and enhanced phosphoinositide hydrolysis. 2. Pharmacological manipulations that elevate cAMP or stable analogues of cAMP attenuate the acetylcholine (ACh)-induced enhancement of phosphoinositide hydrolysis. We postulate that cross-talk between adenylate cyclase and phospholipase C signal transducing systems probably exists in rat retina, as has been described for other systems. 3. Intraocular administration of pertussis toxin attenuated the response of both adenylate cyclase and phospholipase C to muscarinic stimulation, suggesting that some retinal muscarinic receptors are apparently coupled to their effector systems via pertussis toxin sensitive G proteins.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00734809
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  • 3
    Digitale Medien
    Digitale Medien
    Inhibition of dopamine-activated adenylate cyclase and dopamine binding by opiate receptors in rat striatum (1983)
    Springer
    Cellular and molecular neurobiology 3 (1983), S. 17-26 
    Details
    ISSN: 1573-6830
    Schlagwort(e): dopamine ; opiates ; adenylate cyclase ; striatum
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary 1. Low-affinity (micromolar)3H-dopamine binding was measured under conditions which permitted dopamine activation and opiate inhibition of adenylate cyclase in rat striatal membranes. Opiate drugs and peptides inhibited the dopamine binding in the presence of both GTP5 and Gpp(NH)p. Opiate inhibition of adenylate cyclase was, however, observed only in the presence of GTP. 2. It is suggested that the dopamine D1 receptor in striatum may be modulated by the opiate delta receptor through a shared guanine nucleotide binding subunit.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00734995
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