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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 276 (1973), S. 413-420 
    ISSN: 1432-1912
    Keywords: Tetanus Intoxication ; Local Tetanus ; Pathological Gamma-Bias
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Local tetanus in the right hind leg of the cat was caused by injecting tetanus toxin subcutaneously at the right triceps surae muscle. The left side, which showed no pathological symptoms, was used as control. 2. The muscles of both sides were stretched linearly at a very slow rate (0.02 to 0.2 mm/sec). We compared the electrical mass activity of the bundle from dorsal roots L7 and S1 in response to muscle stretch of the control and the pathological side. 3. Both before and during the linear stretching the afferent activity was stronger on the intoxicated than on the control side. 4. It is concluded that during local tetanus the rough pathological augmentation of the basis in the gamma system was about 10 mm or more, and that the change of the gamma bias in the intoxicated preparation is beyond the physiological range.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 276 (1973), S. 421-436 
    ISSN: 1432-1912
    Keywords: Local Tetanus ; Stretch Reflex ; Tension-Extension Curve ; Gamma Bias
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Tetanus toxin was injected into one triceps surae muscle of the cat to obtain symptoms of local tetanus. The contralateral homologous muscle was used as a control. 2. The incubation time (20–40 h) was linearly related to the cube root of the weight of cat and showed a constant velocity (7–9 mm/h) of the spreading of toxin in the nerve fibres in cats of various sizes. 3. The tension-extension curves of the tetanus muscle showed more stiffness and the base of the exponential passive tension-extension curve was always greater in the tetanus triceps surae muscle than in the control. 4. With repeated stretches of the poisoned muscle the total tension-extension curve showed a progressive parallel shift to the right, indicating threshold increase of the stretch reflex. With antagonistic nerve stimulation the curve shiftet to the left (facilitation), which was never seen in the normal state. 5. The total tension-extension curve of the poisoned muscle showed a progressive parallel shift to the left during the first few hours after the onset of symptoms, and to the right during selective blocking of the gamma fibres by procaine. 6. The cats in which the toxin was injected into the flexor (tibialis anterior) muscle, had a longer incubation time and developed extensor spasticity instead of flexion of the leg. 7. It is concluded that bias augmentation of the extensor gamma system is mainly responsible for the muscular stiffness in the early period of local tetanus.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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