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  • 1
    Electronic Resource
    Electronic Resource
    Augmentation of impaired tumoricidal function in alveolar macrophages from lung cancer patients by cocultivation with allogeneic, but not autologous lymphocytes (1997)
    Springer
    Cancer immunology immunotherapy 45 (1997), S. 29-36 
    Details
    ISSN: 1432-0851
    Keywords: Key words Alveolar macrophages ; Tumoricidal activity ; PBL ; Lung cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  It has been reported that the in vitro development of tumoricidal function in alveolar macrophages from lung cancer patients is reduced significantly when compared to that in peripheral blood monocytes from the same patients or alveolar macrophages from control patients. In the present investigation, a method for potentiating the development of tumoricidal function in alveolar macrophages from lung cancer patients is described. This method, which relies on priming the macrophages with purified, allogeneic peripheral blood lymphocytes from normal donors, could not be demonstrated when autologous lymphocytes from lung cancer patients were used in the priming coculture. The augmentation of tumoricidal function appears to be mediated by one or more soluble factors, since supernatants from cocultures of alveolar macrophages and allogeneic peripheral blood lymphocytes could enhance the cytotoxic function of freshly obtained alveolar macrophages. Furthermore, it appears that NK cells are necessary for this effect, since depletion of CD56+/CD57+ cells from allogeneic lymphocytes eliminated their capacity to enhance alveolar macrophage cytotoxic function. The augmentation of cytotoxic function elicited in alveolar macrophages by this method was not associated with changes in the secretion of tumor necrosis factor α, or interleukin 1β.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002620050397
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Modulation of tumoricidal function in alveolar macrophages from lung cancer patients by interleukin-6 (1997)
    Springer
    Cancer immunology immunotherapy 45 (1997), S. 37-44 
    Details
    ISSN: 1432-0851
    Keywords: Key words Alveolar macrophages ; Tumoricidal activity ; PBL ; Interleukin-6 ; Lung cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Previous studies have demonstrated that alveolar macrophages from lung cancer patients are impaired in their ability to develop tumoricidal function when stimulated by activators such as interferon γ + lipopolysaccharide. However, these same macrophages have been shown to develop significant tumoricidal function when precultured with macrophage-depleted allogeneic peripheral blood lymphocytes from normal donors, an effect that was lost by the elimination of natural killer cells from the allogeneic lymphocyte population. In the present study, the effect of each activation condition on the expression of mRNA for interleukin-1α (IL-1α), IL-1β, tumor necrosis factor α (TNFα) and IL-6 was determined using reverse transcription/polymerase chain reaction. The results show that the non-permissive activation condition is associated with the expression of mRNA for IL-6 while the permissive activation condition is not. Antibodies against IL-6 were subsequently shown to permit the development of tumoricidal function in alveolar macrophages stimulated with interferon γ + lipopolysaccharide while IL-6 protein was shown to inhibit the stimulatory action of allogeneic lymphocytes on the development of tumoricidal function in the same alveolar macrophages. Neither the permissive (i.e. allogeneic lymphocyte stimulation) nor the non-permissive (i.e. interferon γ + lipopolysaccharide) activation condition had any effect on the capacity of alveolar macrophages from lung cancer patients to express mRNA for IL-1α, IL-1β or TNFα. These results show that IL-6 can regulate the ability of alveolar macrophages from lung cancer patients to be stimulated by interferon γ + lipopolysaccharide to develop significant tumoricidal function. They also show that allogeneic lymphocytes have the capacity to down-regulate IL-6 mRNA synthesis by alveolar macrophages thereby permitting the development and/or expression of macrophage tumoricidal function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002620050398
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of reappearance of fixated and attended stimuli upon saccadic reaction time (1990)
    Springer
    Experimental brain research 81 (1990), S. 318-324 
    Details
    ISSN: 1432-1106
    Keywords: Attention ; Fixation ; Saccadic reaction time Human
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of visual attention and fixation upon the distribution of saccadic latencies: express (E-), fast regular (FR-), and slow regular (SR-) saccades were investigated. Extinguishing a fixation or an attention point 200–300 ms before target onset increases the incidence of E-saccades while concurrently decreasing the proportion of SR-saccades. Since this extinction forces a disengaging of attention, these changes in relative proportions of saccades reflect the elimination of one of the steps involved in programming saccades. It is shown that a previously attended stimulus has a favored status relative to other stimuli in the visual field. If, after being turned off, the previously attended fixation point or a peripheral attention stimulus is turned on near the time of the target's appearance, the occurrence of the E-saccades is greatly reduced. However, the appearance of any other stimulus in the visual field at or near the time of the target onset does not inhibit E-saccades. Contrary to the conclusions reached by Posner and Cohen (1984), a stimulus presented at the formerly attended location can attract attention more efficiently than a stimulus presented at another, new location.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00228122
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Relationship between directed visual attention and saccadic reaction times (1988)
    Springer
    Experimental brain research 73 (1988), S. 546-552 
    Details
    ISSN: 1432-1106
    Keywords: Attention ; Fixation ; Saccades ; Saccadic reaction times
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Saslow (1967) and Fischer and Ramsperger (1984) found that saccadic reaction time (SRT) depends on the interval between the fixation point offset and the target onset. Using a continuously visible fixation point, we asked whether a similar function would be obtained if subjects attended to a peripherally viewed point extinguished at variable intervals before or after the target onset. The interval was varied between -500ms (i.e., attention stimulus offset after saccade target onset = overlap trials) and 500ms (i.e., attention stimulus offset before saccade target onset = gap trials). The results show a constant mean SRT of about 240 ms for overlap trials, and a U-shaped function with a minimum of 140 ms, at a gap duration of 200 ms, for gap trials. These findings suggest that saccadic latencies do not depend on the cessation of fixation per se, but rather on the disengagement of attention from any location in the visual field. The time required for subjects to disengage their attention is approximately 100 ms. This disengaged state of attention — during which short latency (express) saccades can be made — can be sustained only for a gap duration of 300 ms. At longer gap durations mean SRTs increase again.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00406613
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    Paper (German National Licenses)
    Fulltext
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