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  • Key words composite plates  (1)
  • M1-receptors  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archive of applied mechanics 66 (1995), S. 126-133 
    ISSN: 1432-0681
    Keywords: Key words composite plates ; periodic structure ; refined scaling ; microdynamics correction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Summary  The subject of the contribution is an investigation of elastic composite plates with a microperiodic structure along the plate’s midsurface. The computational models of the plates are largely based on the homogenization procedures leading to equations with constant coefficients. However, the homogenization theories neglect the microstructure length-scale effect on the plate’s dynamic behaviour. The objective of this research is to formulate and investigate a refined theory of the composite plates under consideration, which would describe the microdynamic plate behaviour caused by the microstructure. The possible applications of the proposed theory are shown by an example.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 341 (1990), S. 165-170 
    ISSN: 1432-1912
    Keywords: Antimuscarinics ; Telenzepine ; M1-receptors ; Gastric acid secretion ; Mouse isolated stomach
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An attempt was made to characterize the muscarine receptor type(s) involved in acid secretion in the mouse isolated stomach when stimulated by the muscarinic agonist McN-A-343. A series of 8 muscarinic antagonists was used with preference for Mr receptors (telenzepine and pirenzepine), M1 and M2 receptors (secoverine), M2 receptors (AF-DX 116 and himbacine) and M1 and M3 receptors (p-F-HHSiD and HHSiD). BTM-1086 was used as a high affinity antagonist at the M1 receptor however with little selectivity. Receptor type preferences were determined in binding experiments with [3H]telenzepine in cortical membranes (M1) and [3H]N-methylscopolamine in atrial (M2) or salivary gland (M3) membranes, derived from guinea pigs. No antagonist with M3 preference could be identified in the binding studies. A fixed antagonist concentration of 1 μmol/l was used to antagonize acid secretion stimulated by 10 μmo1/l McN-A-343. By plotting the percentage inhibition obtained in the functional test against the Ki values determined in binding experiments for each antagonist at M1, M2 and M3 binding sites, an affinity-inhibition curve could only be constructed when based on the antagonist affinities to the Mr receptor. No statistically significant fit was found using antagonist affinities to the M2 or M3 receptor. Thus, in accordance with the presumed Mr selectivity of the agonist McN-A-343, the rank order of potencies of different antagonists point to the M1 nature of the muscarine receptor which stimulates acid secretion in the mouse isolated stomach upon activation by McN-A-343. Though M2 receptors were completely ruled out, M3 receptors may still contribute to some extent to the acid stimulating effect of McN-A-343 in this tissue.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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