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Digitale Medien

Effects of antidepressant agents on open field behaviour in rats (1973)

Kulkarni, S. K. ; Dandiya, P. C.

Springer

Psychopharmacology 33 (1973), S. 333-338

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Details

ISSN: 1432-2072

Schlagwort(e): Stereotyped Behaviour ; Tricyclic Compounds ; MAOIs

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Influence of acute and chronic administration of two types of antidepressant drugs i.e. tricyclic compounds and monoamine oxidase inhibitors (MAOIs), on the Open Field behaviour in rats was examined. Two types of stereotyped behaviour were observed in the open field test namely simple stereotypy (ambulation) and complex stereotypy (rearing). Chronic administration of MAOIs primarily caused an increase in the simple stereotyped behaviour while tricyclic compounds on repeated administration selectively increased complex stereotyped behaviour. The Open Field behaviour of rats due to MAOIs is comparable to hallucinogens while the pattern seen with tricyclic agent differs from MAOIs and other central nervous system stimulant drugs.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00437510

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