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  • 1
    Electronic Resource
    Electronic Resource
    Neuroendocrine evidence for serotonin receptor hypersensitivity in panic disorder (1988)
    Springer
    Psychopharmacology 96 (1988), S. 360-364 
    Details
    ISSN: 1432-2072
    Keywords: Serotonin ; Receptor hypersensitivity ; Anxiety ; Cortisol ; Panic disorder ; MCPP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Normal controls (NC) (n=15), patients with panic disorder (PD) (n=13) and patients with major depression (MD) (n=17) were challenged with a single, oral dose (0.25 mg/kg) of the selective 5HT agonist m-chlorophenyl-piperazine (MCPP) or placebo. Blood samples were assayed for cortisol and MCPP levels every 30 min. The PD group had an augmented cortisol release when compared to the other two groups. Finally, a significant correlation was found across all subjects between clinical anxiety level and cortisol release on MCPP. These data support the hypothesis of 5HT receptor hypersensitivity in PD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00216062
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A dose-response study of intravenousm-chlorophenylpiperazine in normal subjects (1992)
    Springer
    Psychopharmacology 106 (1992), S. 388-390 
    Details
    ISSN: 1432-2072
    Keywords: MCPP ; Serotonin ; Dose-response ; Intravenous
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A placebo-controlled dose-response study of the direct serotonin receptor agonistm-chlorophenylpiperazine (MCPP), intravenously infused over 90 s in 0.06 and 0.08 mg/kg doses, was conducted in nine normal male subjects. Cortisol, prolactin, MCPP serum levels and behavioral responses were measured over a 210-min period. Both doses caused significant cortisol and prolactin release and were associated with significantly greater behavioral effects as compared to placebo. Though the two doses were associated with different MCPP serum levels, they did not significantly differ in their hormonal and behavioral effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245423
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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