ISSN:
1432-0428
Keywords:
Diabetes mellitus
;
Indian Asian
;
MHC
;
tumour necrosis factor
;
linkage disequilibrium
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Tumour necrosis factor gene polymorphism has been proposed as a determinant of Type 1 (insulin-dependent) diabetes mellitus. Tumour necrosis factor-beta gene polymorphisms were analysed in 40 North Indian Asian Type 1 diabetic patients and 63 control subjects. A 5.5 kilobase gene fragment was significantly increased among the patients (82.5% vs 52%, p c〈0.01). A 10.5 kilobase fragment was significantly reduced among the patients (70% vs 90.5%, p c〈0.02). The 5.5 kilobase fragment was associated with DR3, and was not significantly increased among DR3-positive patients compared with DR3-positive control subjects. The 5.5 kilobase/5.5 kilobase genotype was increased among the diabetic subjects (30% vs 9.5%, p c〈0.03). The 10.5 kilobase/10.5 kilobase genotype was reduced among the diabetic subjects (17.5% vs 47.5%, p c〈0.02). The 5.5 kilobase/10.5 kilobase genotype was not significantly associated with disease. These findings contrast with those in a white Caucasian population, suggesting that tumour necrosis factor-beta polymorphisms do not predispose to Type 1 diabetes directly, but are in linkage disequilibrium with disease susceptibility alleles at other MHC loci.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00400276
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