ISSN:
1573-4927
Schlagwort(e):
HUMAN NEURONAL PROTEIN 17.3
;
MOUSE NP15.6
;
CDNA CLONING
;
TISSUE EXPRESSIONAL
;
CHARACTERIZATION
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Biologie
,
Chemie und Pharmazie
Notizen:
Abstract A full-length cDNA of 595 bp was isolated froma human fetal brain cDNA library. It contains an openreading frame encoding 153 amino acids, with an 18-bp5′UTR and a 118-bp 3′UTR in which there isan atypicalpolyadenylation signal (ATTAAA). The calculatedmolecular weight of the deduced protein is 17.3 kU. Thepredicted isoelectric point is 4.89. On account of itshigh homology to mouse neuronal protein NP15.6(81.2% identity), the deduced protein was namedneuronal protein 17.3 (NP17.3). When its secondarystructure was examined by the GGBSM program of PCGENEsoftware, it was found that 32.6 and 15.0% of itsamino acids are involved in formingalpha-helices and beta-sheets, respectively. Examinedwith the PESTFIND program, a typical PEST region foundin rapidly degraded proteins was found between residue48and residue 68.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1023/A:1018734605214
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