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  • 1
    Electronic Resource
    Electronic Resource
    Protection against post-ischaemic neuronal loss in gerbil hippocampal CA1 by glycine b and AMPA antagonists (1997)
    Springer
    Journal of neural transmission 104 (1997), S. 1249-1254 
    Details
    ISSN: 1435-1463
    Keywords: Forebrain ischaemia ; gerbil ; glycine b antagonists ; MRZ 2/570 ; MRZ 2/576 ; NBQX ; hippocampus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Novel antagonists of the glycineB site of the NMDA receptor (MRZ 2/570, MRZ 2/576), and an AMPA receptor antagonist, NBQX were tested in 3-min. global ischaemia in gerbils. Untreated animals showed after 14 days a loss of almost 90% of pyramidal neurones in the CA1 region, which was prevented by NBQX, and reduced to 50% by both glycineB antagonists. NBQX produced a delayed, long lasting (up to 24 hr) hypothermia while hypothermia with both glycineB antagonists was transient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01294724
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    GlycineB antagonists as potential therapeutic agents (1998)
    Springer
    Amino acids 14 (1998), S. 235-239 
    Details
    ISSN: 1438-2199
    Keywords: NMDA receptors ; Glutamate ; Behaviour ; MRZ 2/570 ; MRZ 2/576 ; L-701,324
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary It is not clear what therapeutic application is most likely for agents blocking glycine site of the NMDA receptors (glycineB). Majority of the studies to date used either glycineB antagonists with doubtful brain penetration or partial agonists. Following systemic administration to rats of our newly developed glycmeB antagonists (MRZ 2/570; 2/571 and 2/576) and L-701,324 (MSD) as a reference agent the following behavioural effects were observed: weak (if any) antiparkinsonian-like effects, lack of anxiolytic activity, inhibition of physical and motivational aspects of morphine dependence and neuroprotective activity in global ischaemia. The side effects include: sedation, ataxia, and myorelaxation. We detected neither vacuolisation in the cingulate cortex nor impairment of pre-pulse inhibition indicating lack of psychotomimetic potential.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01345268
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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