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  • 1
    ISSN: 1432-1106
    Keywords: Vasopressin release ; Brain muscarinic receptors ; Brain nicotinic receptors ; Increased plasma osmolality ; Hemorrhage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary There is considerable evidence to suggest that there is a cholinergic link in the neural control of vasopressin release, but the precise role for this link has not been adequately demonstrated in the intact animal. We have, therefore, examined in conscious unrestrained rats the effects of central cholinergic blockade on the stimulation of vasopressin release by increased plasma osmotality (iv infusion of 2.5 M NaCl at 0.1 mg/kg body weight · min for 30 min) and by decreased blood volume (2 successive hemorrhages of 10% of blood volume each). The vasopressin responses to these stimuli were unaffected by either intracerebroventricular (icv) atropine (10 μg; muscarinic blockade) or icv hexamethonium (10 μg; nicotinic blockade) in doses which block the vasopressin responses to icv cholinergic agonists. The implications of these findings are discussed.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1435-1803
    Keywords: vasopressin ; hemorrhage ; Macaca fascicularis ; baroreceptors ; primate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An 6 Affen (Macaca fascicularis) wurden die Beziehungen zwischen arteriellem Druck, Plasma-Arginin-Vasopressin sowie linksventrikulärem enddiastolischem Druck und Plasma-Vasopressin als Antwort auf eine in 2 Stufen durchgeführte Blutaufnahme untersucht. Nach jeder Blutentnahme traten eine signifikante Abnahme des arteriellen Drucks, eine signifikante Steigerung der Plasma-Vasopressinkonzentration sowie variable, aber nicht signifikante Änderungen des linksventrikulären enddiastolischen Drucks in Erscheinung. Diese Ergebnisse sind mit der Hypothese vereinbar, daß beim Primaten Druckrezeptoren im arteriellen System für die Vasopressinsektretion und Volumenkontrolle bedeutsamer sind als Rezeptoren im Niederdrucksystem.
    Notes: Summary Experiments were carried out in sixMacaca fascicularis monkeys to determine the relationships between arterial pressure (AP) and plasma arginine vasopressin (AVP) and left ventricular enddiastolic pressure (LVEDP) and plasma AVP in response to a two-step hemorrhage. In response to each hemorrhage, there occurred a significant decline in AP, a significant elevation of plasma AVP and variable but nonsignificant changes in LVEDP. These results are consistent with the hypothesis that in the primate high pressure receptors are more important than low pressure receptors in the volumetric control of AVP secretion.
    Type of Medium: Electronic Resource
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