ISSN:
1432-0878
Keywords:
Microglia
;
Macrophages
;
Chemical lesion
;
Kainic acid
;
Hippocampus
;
Rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Light-and electron-microscopic investigations of kainic acid-induced lesions revealed a marked macrophage response and “microgliocytosis”. The hematogenous origin of reactive elements, such as brain macrophages and “microglia-like reactive cells”, was demonstrated when blood phagocytes were labeled with carbon particles or horseradish peroxidase prior to induction of the kainic acid-lesion. The induced lesion showed a proliferation of microglial cells, which led to a state of “microgliocytosis” in the later stage of lesioning. Since it is now generally accepted that microglial cells in the state of “microgliocytosis” are derived from the “microglia-like reactive cells”, proliferated microglial cells in the brain lesions are probably of hematogenous origin. The relationships among the brain macrophages, the “microglia-like reactive cells” and the intrinsic microglial cells are discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00210092
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