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  • 1
    Electronic Resource
    Electronic Resource
    Proton magnetic resonance spectroscopy (1H-MRS) for the evaluation of treatment of brain tumours (1995)
    Springer
    Neuroradiology 37 (1995), S. 99-103 
    Details
    ISSN: 1432-1920
    Keywords: Magnetic resonance spectroscopy ; Brain tumours ; N-acetyl-aspartate ; Lactate ; Embolisation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated metabolic changes in brain tumours following treatment, using proton magnetic resonance spectroscopy. In meningiomas, effective therapeutic embolisation led to an acute increase in lactate. In radiosensitive tumours such as malignant lymphoma, a decrease in lactate and in increase inN-acetyl-aspartate occurred after radiotherapy, which preceded changes observed on magnetic resonance imaging. On the other hand, no significant changes in spectral patterns were observed in malignant gliomas resistant to therapy. Tissue characterisation of brain tumours by spectral patterns on proton magnetic resonance spectroscopy remains controversial. However, we have shown it to be sensitive to metabolic changes following treatment, which may reflect the efficacy of the therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00588621
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Metabolic and neurological patterns in chronic cerebral infarction: a single-voxel 1H-MR spectroscopy study (1997)
    Springer
    Neuroradiology 39 (1997), S. 560-565 
    Details
    ISSN: 1432-1920
    Keywords: Key words Brain metabolism ; Cerebral infarcts ; chronic ; Magnetic resonance spectroscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The details of brain metabolism in chronic cerebral infarcts have not been clarified. Using proton MR spectroscopy (1H-MRS) at 1.5 T, we measured biochemical changes in 16 patients with large infarcts involving the motor cortex in the chronic phase (median 293.9 days) and related the findings to clinical data. Localised spectra were obtained using point-resolved spectroscopy, with an echo time of 270 ms. Regions of interest were placed on the frontal lobe, including the precentral gyrus and central sulcus. Motor function was assessed by the manual muscle power test at the time of the 1H-MRS study. Only three patients with severe paresis had no signal in the lesions and a lactate signal was obtained in 13 cases. N -acetyl aspartate (NAA) was observed in 4 cases with recanalisation of an occluded vessel. Motor function correlated strongly with the NAA/choline-containing compounds (Cho) ratio (P 〈 0.01) and lactate/Cho ratio (P 〈 0.01). We found various metabolic patterns, reflecting residual neurological function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050467
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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