Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 278 (1986), S. 465-469 
    ISSN: 1432-069X
    Keywords: Percutaneous absorption ; Man ; Anatomic site ; Stripping method
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The influence of anatomic site on the relationship between total penetration of a molecule and its quantities present in the stratum corneum (SC) 30 min after application was quantified in an in vivo study. For each site, six male volunteers received two symmetrical applications of 1,000 nmol benzoic acid 14C to an area of 1 cm2 for 30 min. The first application permitted measurement of total absorption of benzoic acid within 4 days (urinary excretion method), while the second enabled determination of the quantity of benzoic acid in the SC at the end of the application time. Total penetration according to site is: back 〈 arm 〈 chest 〈 thigh 〈 abdomen 〈 forehead, (with the forehead being three times more permeable than the back). Whatever the sites and the origin of the differences observed, the results show that the single measurement of the amounts of a compound present in the SC at 30 min postapplication appears sufficient to predict its total penetration, these two parameters being linearly correlated (r=0.97, P〈0.001).
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 271 (1981), S. 241-244 
    ISSN: 1432-069X
    Keywords: Percutaneous penetration ; Man ; Animal ; Urine ; Wet ash ; Hautpenetration ; Mensch ; Tier ; Urin ; Feucht-Veraschung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Pharmakokinetische Untersuchungen mit tierischer und menschlicher Haut werden oft vorzugsweise mit niedrigen Spiegeln von C14 durchgeführt. Wir stellen eine effiziente Feucht-Veraschungsmethode vor, die erlaubt, 20 dpm pro Ansatz zu erfassen, was dem doppelten Basiswert entspricht. So können vollständige Untersuchungen mit 1 μCi oder weniger von C14 pro Versuchsobjekt durchgeführt werden.
    Notes: Summary Pharmacokinetic studies of animal and human skin are often advantageously performed with low levels of C-14. We detail an efficient wet ashing method capable of detecting 20 dpm per sample, equivalent to twice the background level, thus permitting complete kinetic assays with 1 μCi or less of C-14 per subject.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...