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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    International archives of occupational and environmental health 61 (1988), S. 107-113 
    ISSN: 1432-1246
    Keywords: Mandelic and phenylglyoxylic acid excretion kinetics ; Styrene accumulation ; Styrene industrial exposure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The excretion kinetics of mandelic and phenylglyoxylic acids investigated over three subsequent days after cessation of styrene inhalation could be expressed by biphasic functions, similar for both metabolities; the half-times for the first and the second phases were 2.5 and 30 h, respectively. The possibility of styrene accumulation in exposure repeated daily was assessed by kinetic modelling; it appears negligible if measurements are based on urine samples collected at the end of the working shift. The above contention has been examined in workers exposed to styrene in the polyester industry: concentrations of styrene in air monitored continuously varied from 26 to 130 mg/m3. The relationship between styrene concentration and rate of urinary excretion of the total amount of mandelic and phenylglyoxylic acids was rectilinear and demonstrated a reasonable agreement between experimental and industrial data. The trends of concentrations within the day and week gave no indication of substantial styrene cumulation under repeated industrial exposure.
    Type of Medium: Electronic Resource
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