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  • 1
    Electronic Resource
    Electronic Resource
    The effect of lithium chloride administration on brain and heart norepinephrine turnover rates (1969)
    Springer
    Psychopharmacology 14 (1969), S. 315-322 
    Details
    ISSN: 1432-2072
    Keywords: Lithium ; Norepinephrine ; Kinetics ; Brain Chemistry ; Manic-Depressive Psychoses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of Li+ on NE turnover rates in rat heart and brain was studied. Turnover rates were determined in brain and heart by blocking tyrosine hydroxylase with L-α-methyltyrosine and following the decline of NE with time or in heart by injecting3H-NE and following the decline of NE specific activity with time. Subacute treatment with LiCl in doses that maintained a serum lithium level within the clinically therapeutic range caused: 1. A 95% increase in brain NE turnover rate without altering the steady-state level of the amine. 2. A slight but not significant increase in heart NE turnover. 3. The selective increase in brain NE turnover, compared to heart, may be attributed to the higher tissue levels of Li+ found in the brain under the conditions of study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02190116
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  • 2
    Electronic Resource
    Electronic Resource
    Modulation of muscarinic receptor-mediated adenylate cyclase and phospholipase C responses in rat retina (1991)
    Springer
    Cellular and molecular neurobiology 11 (1991), S. 455-462 
    Details
    ISSN: 1573-6830
    Keywords: muscarinic receptors ; adenylate cyclase ; cyclic AMP ; phosphoinositide hydrolysis ; phorbol esters ; pertussis toxin ; cholera toxin ; rat retina
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. Agonist activation of rat retina muscarinic receptors results in suppression of cyclic AMP (cAMP) generation and enhanced phosphoinositide hydrolysis. 2. Pharmacological manipulations that elevate cAMP or stable analogues of cAMP attenuate the acetylcholine (ACh)-induced enhancement of phosphoinositide hydrolysis. We postulate that cross-talk between adenylate cyclase and phospholipase C signal transducing systems probably exists in rat retina, as has been described for other systems. 3. Intraocular administration of pertussis toxin attenuated the response of both adenylate cyclase and phospholipase C to muscarinic stimulation, suggesting that some retinal muscarinic receptors are apparently coupled to their effector systems via pertussis toxin sensitive G proteins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00734809
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    Paper (German National Licenses)
    Fulltext
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