ISSN:
1432-0533
Keywords:
Membrane-type matrix metalloprotease
;
Gelatinase A
;
Human brain
;
Microglia
;
β-Amyloid
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Membrane-type matrix metalloprotease (MT-MMP) is an activator of gelatinase A (MMP-2), which has previously been found in carcinoma cells. We examined non-neurological and Alzheimer's disease brain tissues for MT-MMP by immunohistochemistry and in situ hybridization. The anti-MT-MMP antibodies gave positive staining of brain microglial cells in all the brain tissues. Positively stained microglia were found only in the white matter. The cells producing MT-MMP protein were also shown to be white matter microglia. These results provide further evidence that activated gelatinase A, which may be a processing enzyme for degradation of β-amyloid protein, may be produced in white matter microglia.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00294800
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