ISSN:
1438-2199
Schlagwort(e):
Amino acids
;
Methyl 2-carbamoylimino-3,3,3-trifluoropyruvate
;
Trifluoromethyl substituted 2,5-dioxopiperazines
;
4-Trifluoromethyl N-carboxy anhydrides
;
4-Trifluoromethyl-4H-oxazolones-5
;
Ugi reaction
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary Methodology for the synthesis and incorporation ofα-trifluoromethyl substituted amino acids into N- and C-terminal position of peptides is described. The incorporation ofα-trifluoromethyl substituted amino acids into strategical positions of peptides enhances proteolytic stability and lipophilicity. Furthermore, it improves transport rates in vivo and permeability through certain body barriers.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00806491
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