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  • Micropuncture  (3)
  • Nuclear reactions  (2)
  • Pineoblastoma  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Renal effects of furosemide in glycerol induced acute renal failure of the rat (1976)
    Springer
    Pflügers Archiv 365 (1976), S. 81-87 
    Details
    ISSN: 1432-2013
    Keywords: Renal failure ; Micropuncture ; Diuretics ; Glomerular filtration rate ; Effective filtration pressure ; Renal blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The renal effects of furosemide in acute renal failure of the rat were studied using clearance and micropuncture techniques. Acute renal failure was induced by an intramuscular injection of 50% glycerol (10 ml/kg). Functional impairement of the glycerol treated animals consisted of a decrease in urinary sodium excretion, renal blood flow, total kidney GFR and effective filtration pressure of superficial nephrons. Effective filtration pressure was calculated from proximal free flow and stop flow pressure measurements. In contrast to control animals furosemide did not increase urine volume during acute renal failure due to a marked fall in GFR. Renal blood flow, as measured by an electromagnetic flowmeter, also decreased after furosemide in glycerol treated rats and increased in control animals. Furosemide reduced effective filtration pressure during acute renal failure to almost zero, whereas in control animals effective filtration pressure virtually remained constant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00583631
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of ozolinone, a diuretic active metabolite of etozoline, on renal function (1978)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 304 (1978), S. 289-296 
    Details
    ISSN: 1432-1912
    Keywords: Diuretics ; Clearance technique ; Micropuncture ; Tubular function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of ozolinone (3-methyl-4-oxo-5-piperidino-thiazolidine-2-ylidene) on renal tubular and glomerular functions were studied in rats using clearance and micropuncture techniques. Ozolinone (50 mg·kg−1 i.v., 50 mg·kg−1·h−1i.v.) markedly increased urine volume, urinary sodium excreation and — to a minor extent — also urinary potassium excretion. Fractional tubular sodium reabsorption fell by 14%. Renal blood flow, as measured by an electromagnetic flowmeter, increased considerably during the administration of the drug. Despite the fact that ozolinone increased intratubular hydrostatic pressure, whole kidney as well as single nephron GFR—measured at different tubular sites — remained constant due to an increase in glomerular capillary pressure (stopped flow measurements, servo nulling technique). The diuretic decreased intrinsic reabsorptive capacity of the proximal tubular epithelium as measured with the shrinking drop technique of Gertz, but had no clearcut effects on proximal fractional reabsorption. Fractional reabsorption was evaluated not only from free flow endproximal tubular fluid to plasma inulin measurements but also from transit time and half time of reabsorption (shrinking drop technique). An impressive depression of fluid, sodium and potassium reabsorption occurred in the loops of Henle after ozolinone. No further inhibition of fluid and sodium reabsorption in the distal convoluted tubules could be detected after the drug using a free flow recollection technique. Concerning the tubular site of renal action there is a striking similarity between ozolinone and the strong acting diuretic furosemide, although the chemical structures of these drugs are quite different. Differences between the two drugs exist concerning the endproximal tubular chloride concentration, which was decreased by furosemide but was not affected by ozolinone. This points to different effects of the drugs on proximal tubular bicarbonate reabsorption.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00507971
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Angular distribution of tensor polarizations in ^2H(α, ^5He^g^.^s)p from the sequential decay reaction ^2H(α,p)^5He^g^.^s(α)n
    Amsterdam : Elsevier
    Nuclear Physics, Section A 286 (1977), S. 142-162 
    Details
    ISSN: 0375-9474
    Keywords: Nuclear reactions
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0375-9474(77)90013-6
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The sequential decay ^1^0B(α, α)^1^0B^*(α)^6Li at E"α = 24 MeV
    Amsterdam : Elsevier
    Nuclear Physics, Section A 228 (1974), S. 229-245 
    Details
    ISSN: 0375-9474
    Keywords: Nuclear reactions
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0375-9474(74)90429-1
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Pleomorphic pineocytoma with extensive neuronal differentiation: report of two cases (1994)
    Springer
    Acta neuropathologica 88 (1994), S. 448-453 
    Details
    ISSN: 1432-0533
    Keywords: Pineal parenchymal tumors ; Pineocytoma ; Pineoblastoma ; Central neurocytoma ; Neuronal differentiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two pineal parenchymal tumors are presented, arising in a 54-year-old man and a 72-year-old woman; respectively. They showed isomorphic, cellular areas of small cells, often with characteristic pineocytomatous rosettes, and of medium-sized cells, as well as less cellular regions with highly pleomorphic, often ganglioid large cells. Immunohistochemistry disclosed extensive neuronal differentiation. There was intense positivity for neurofilament protein and microtubule-associated protein 2 in the pleomorphic areas and more variable expression in the isomorphic regions. Diffuse synaptophysin positivity was seen, accentuated along the borders of pleomorphic cells and in the rosettes, as well as diffuse interstitial and/or cytoplasmic expression of neuron-specific enolase, PGP 9.5 and tau. β-Tubulin III was detected in most cells and slight positivity was found in the rosettes. Expression of glial fibrillary acidic protein, however, was restricted to resident astrocytes and an interstitial network of processes. These neuronally differentiated pleomorphic pineocytomas under-line the broad histomorphological spectrum of pineal parenchymal tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00389497
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Pleomorphic pineocytoma with extensive neuronal differentiation: report of two cases (1994)
    Springer
    Acta neuropathologica 88 (1994), S. 448-453 
    Details
    ISSN: 1432-0533
    Keywords: Key words Pineal parenchymal tumors ; Pineocytoma ; Pineoblastoma ; Central neurocytoma ; Neuronal differentiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two pineal parenchymal tumors are presented, arising in a 54-year-old man and a 72-year-old woman; respectively. They showed isomorphic, cellular areas of small cells, often with characteristic pineocytomatous rosettes, and of medium-sized cells, as well as less cellular regions with highly pleomorphic, often ganglioid large cells. Immunohistochemistry disclosed extensive neuronal differentiation. There was intense positivity for neurofilament protein and microtubule-associated protein 2 in the pleomorphic areas and more variable expression in the isomorphic regions. Diffuse synaptophysin positivity was seen, accentuated along the borders of pleomorphic cells and in the rosettes, as well as diffuse interstitial and/or cytoplasmic expression of neuron-specific enolase, PGP 9.5 and tau. β-Tubulin III was detected in most cells and slight positivity was found in the rosettes. Expression of glial fibrillary acidic protein, however, was restricted to resident astrocytes and an interstitial network of processes. These neuronally differentiated pleomorphic pineocytomas underline the broad histomorphological spectrum of pineal parenchymal tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00389497
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Effects of dopamine on whole kidney function and proximal transtubular volume fluxes in the rat (1977)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 296 (1977), S. 289-292 
    Details
    ISSN: 1432-1912
    Keywords: Renal transport ; Dopamine ; β-Adrenoreceptors ; Micropuncture ; Renal blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The renal effects of dopamine were studied using clearance and micropuncture techniques in rats. Intravenous infusion of dopamine (4.7 · 10−6 mol · kg−1 · h−1) increased glomerular filtration rate and renal blood flow. Renal blood flow was measured by an electromagnetic flowmeter. The increase in filtered fluid and sodium was nearly completely matched by increased tubular reabsorption. Thus, only a small rise in urine flow and in urinary sodium excretion was observed. The micropuncture experiments using the split oil droplet method of Gertz demonstrated a stimulation of the transepithelial fluid transfer after injection of dopamine (10−4M) into the proximal tubular lumen. This effect was abolished by simultaneous injection of propranolol (10−3 M) which, by its own, did not affect transtubular volume fluxes. It is concluded that dopamine, by stimulation of β-adrenoceptors, may increase reabsorptive capacity of the proximal tubular epithelium independent of changes in renal hemodynamics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00498695
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    Paper (German National Licenses)
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