ISSN:
1434-4726
Keywords:
Antigen-induced otitis media
;
Human serum albumin
;
Middle ear effusion
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The relationship between antigen levels in middle ear effusions (MEE) and the degree of middle ear inflammation was studied in an antigen-induced otitis media model, using chinchillas sensitized with human serum albumin (HSA). The degree of middle ear inflammation was evaluated by both tympanometric analysis, and cytological and biochemical analyses of the MEE. Middle ear inflammation develops after HSA challenge with a remarkable decrease in HSA levels in the MEE. This inflammation persists even when HSA levels are no longer detectable in the MEE. These findings show that local challenges with an antigen induce a certain degree of middle ear inflammation, which continues even after complete elimination of the antigen from the middle ear through an immunological defense mechanism.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00463547
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