ISSN:
1612-1112
Keywords:
π-π interactions
;
Mobile phase effects
;
Phenyl stationary phase
;
Retinoids
;
Temperature effects
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary The retention behaviour of retinoids, which are π-electron containing solutes, on a phenyl stationary phase was studied using mobile phases consisting of aqueous methanol (MeOH; 76–84 % v/v) and acetonitrile (ACN; 60–82% v/v) at five temperatures (40–60°C). Retention was increasingly affected in both mobile phases by temperature and molecular structure with increasing water content. The effects of mobile-phase are stronger in MeOH and highly aqueous ACN, retention is enhanced. The π-π interactions have a significant effect on the selectivity of chromatographic separations when the sample compounds differ in their electron donor/acceptor capacities.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02275787
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