ISSN:
1432-1912
Keywords:
Key words Cyclic nucleotide-gated channels
;
Second messenger
;
Cyclic GMP
;
Calcium
;
Nitric oxide
;
Molecular cloning
;
Gene family
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Cyclic nucleotide-gated cation channels (CNG channels) form a multi-gene family consisting of at least five distinct members (CNG1–5). Expression studies have indicated that only CNG1–3 are able to form functional homooligomeric channels. Although structurally related, the cDNAs of CNG4–5 fail to induce cyclic nucleotide-dependent currents when expressed alone. However, when co-expressed with CNG1–3 they confer some of the physiologically observed properties of native CNG channels which are absent from the homooligomeric CNG1–3 channels. CNG channels are expressed in several tissues and cell types pointing to a general function of these channels in a wide variety of cellular systems. There is now increasing evidence that a major function of CNG channels may consist in providing a second messenger-regulated pathway for Ca2+ influx.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00168909
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