ISSN:
1432-1912
Keywords:
l-3-Methoxytyrosine
;
Monoamine Synthesis in Rat Brain
;
Dopa
;
5-Hydroxytryptophan
;
NSD 1015 (3-Hydroxybenzylhydrazine HCl)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Rats were injected i.p. with l-3-methoxytyrosine, 100 or 300 mg/kg. One h later brain, liver, heart and blood plama were analyzed for catecholamines and their precursors. In brain Dopa as well as dopamine and noradrenaline levels were unchanged, while demethylation of l-3-methoxytyrosine might have occurred in peripheral organs since Dopa levels in liver and dopamine in heart were elevated. 3-Methoxytyramine could not be detected in brain and liver after treatment with l-3-methoxytyrosine. Monoamine synthesis in vivo was measured in whole brain by determining the accumulation of Dopa and 5-hydroxytryptophan 30 min after the i.p. injection of NSD 1015 (3-hydroxybenzylhydrazine HCl, 100 mg/kg), an inhibitor of the aromatic amino acid decarboxylase. l-3-Methoxytyrosine attenuated the formation of Dopa and 5-hydroxytryptophan by about 25% in brain tissue. The effect was paralleled by a decrease in the brain concentration of tryptophan.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00499948
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