ZIB

Hits per page

hits 1 - 2 | 2 hits

Sorting

Electronic Resource

Adult-onset lysosomal storage disease in a Schipperke dog: clinical, morphological and biochemical studies (1993)

Knowles, K. ; Alroy, J. ; Castagnaro, M. ; [et al.]

Springer

Acta neuropathologica 86 (1993), S. 306-312

add to mindlist on the mindlist

Details

ISSN: 1432-0533

Keywords: Canine galactosialidosis ; Morphology ; Biochemistry

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary An adult-onset lysosomal storage disorder was diagnosed in a 5-year-old Schipperke dog with progressive cerebellar and central vestibular signs. It was characterized by cerebellar atrophy with extensive loss of Purkinje and granular cells, and hydrocephalus. Enlarged and vacuolated neurons were observed in spinal cord and brain; pancreatic centrolobular and islet cells were also vacuolated. Ultrastructurally, enlarged secondary lysosomes laden with lamellated membrane structures were present in neurons and empty enlarged vacuoles were found in pancreatic centroacinar, ductal, and islet cells. On frozen sections neurons stained with Ricinus communis agglutinin-I and wheat germ agglutinin. On paraffin sections neurons stained with luxol fast blue, periodic acid-Schiff, Concanavalia ensiformis agglutinin, and were autofluorescent. These findings indicate an accumulation of glycolipids containing terminal β-galactosyl and α-sialyl residues, and N-linked oligosaccharides. Tissue activity of lysosomal β-galactosidase was 50% of normal and the activity of β-hexosaminidase was elevated. Brain lipid-bound sialic acid was twice normal, with a small increase of GM1-ganglioside, but there was a significant elevation of GM2 (GD2) and GM3 (GD3). In addition, significant elevations of sialylated and non-sialylated oligosaccharides were noted. These clinical, biochemical and pathological findings are similar to those observed in human patients with adult-onset galactosialidosis.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00304147

Permalink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

Electronic Resource

Computation of normal impinging jets in cross-flow and comparison with experiment (1991)

Knowles, K. ; Bray, D.

Chichester : Wiley-Blackwell

International Journal for Numerical Methods in Fluids 13 (1991), S. 1225-1233

add to mindlist on the mindlist

Details

ISSN: 0271-2091

Keywords: Jets ; Vortex flows ; k-ε model ; Finite volume ; Engineering ; Engineering General

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

Notes: The PHOENICS code has been used to model the flow field surrounding subsonic and underexpanded jets impinging on a ground plane in the presence of a cross-flow, for cases with both a fixed ground plane and a ‘rolling road’. The standard k-ε turbulence model is used, without correction factors. It is confirmed that this overpredicts the free jet entrainment rate; the wall jet spreading rate is slightly underpredicted but the initial thickness is too high. Agreement with experiment is, nevertheless, much better than for previous calculations, showing the importance of the extent of the grid used. The ground vortex formed in cross-flow is shown to move with varying effective velocity ratio and with rolling road operation in the same manner as experimentally observed. Ground vortex self-similarity is also accurately predicted with the numerical modelling.

Additional Material: 7 Ill.