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Effect ofPlasmodium berghei infection on benzoic acid metabolism in mice (1985)

Emudianughe, T. S. ; Bickle, Q. D. ; Taylor, M. G. ; [et al.]

Springer

Cellular and molecular life sciences 41 (1985), S. 1407-1409

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ISSN: 1420-9071

Keywords: Mouse liver ; malaria infection ; benzoic acid detoxification ; glucuronic acid conjugation ; hippuric acid

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary The metabolism of benzoic acid was studied inPlasmodium berghei infected mice both in vitro and in vivo. Results of in vitro studies showed a considerable decrease in the ability of the infected liver to detoxify benzoic acid by hippuric acid formation. The in vivo study showed that hippuric acid formation decreases with increasing parasitemia and the emergence of benzoyl-glucoronide. This new pathway stops operating with further increase in parasitemia.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01950007

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